Evidence map›Paper›PMID 37078794›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Ligustrazine Nanoparticle Hitchhiking on Neutrophils for Enhanced Therapy of Cerebral Ischemia-Reperfusion Injury.

Qingchun Mu, Kai Yao, Madiha Zahra Syeda, Min Zhang, Qian Cheng, Yufei Zhang, Rui Sun, Yuting Lu, Huamiao Zhang, Zhicheng Luo and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 79 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 2 countries.

Qingchun MuThe People's Hospital of Gaozhou, Guangdong Medical University, Maoming, 525200, China.
Kai YaoDepartment of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
Madiha Zahra SyedaThe People's Hospital of Gaozhou, Guangdong Medical University, Maoming, 525200, China.
Min ZhangInternational Institutes of Medicine, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, 322000, China.
Qian ChengBasic Medical College, Guilin Medical University, Guilin, 541199, China.
Yufei ZhangBasic Medical College, Guilin Medical University, Guilin, 541199, China.
Rui SunSchool of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, 510515, China.
Yuting LuInternational Institutes of Medicine, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, 322000, China.
Huamiao ZhangInternational Institutes of Medicine, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, 322000, China.
Zhicheng LuoThe People's Hospital of Gaozhou, Guangdong Medical University, Maoming, 525200, China.
Hanning HuangThe People's Hospital of Gaozhou, Guangdong Medical University, Maoming, 525200, China.
Xiaojing LiuThe People's Hospital of Gaozhou, Guangdong Medical University, Maoming, 525200, China.
Chunmei LuoThe People's Hospital of Gaozhou, Guangdong Medical University, Maoming, 525200, China.
Xiulong ZhuThe People's Hospital of Gaozhou, Guangdong Medical University, Maoming, 525200, China.
Shuyu WuDepartment of Neurosurgery, Hainan General Hospical, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, China.
Liao CuiGuangdong Provincial Key Laboratory of Research and Development of Natural Drugs and School of Pharmacy, Guangdong Medical University, Dongguan, 523808, China.
Chunming HuangThe People's Hospital of Gaozhou, Guangdong Medical University, Maoming, 525200, China.
Xiaoyuan ChenDepartments of Diagnostic Radiology, and Surgery, Clinical Imaging Research Centre, Centre for Translational Medicine, Nanomedicine Translational Research Program, NUS Center for Nanomedicine, Yong Loo Lin School of Medicine, Departments of Chemical and Biomolecular Engineering, and Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore, 117597, Singapore.
Longguang TangThe People's Hospital of Gaozhou, Guangdong Medical University, Maoming, 525200, China.ORCID 0000-0002-9517-1325
Guangdong Medical College · CNZhejiang University · CNGuilin Medical University · CNHainan Medical University · CNHarbin Medical University · CNNational University of Singapore · SGSouthern Medical University · CN

Funding

Discipline construction project of Guangdong Medical University 4SG23002GNational Natural Science Fund Cultivating 530 Project of Hainan General Hospital 2022MSXM06natural science foundation of Guangdong province 2020B1515120052Natural Science Foundation of Guangdong Province 2023A1515011386Natural Science Foundation of Guangdong Province 2023A1515012969Science and Technology Planning Project of Maoming 2020KJZX021
6 · The paper itself

Abstract

Ischemic stroke is a refractory disease that endangers human health and safety owing to cerebral ischemia. Brain ischemia induces a series of inflammatory reactions. Neutrophils migrate from the circulatory system to the site of cerebral ischemia and accumulate in large numbers at the site of inflammation across the blood-brain barrier. Therefore, hitchhiking on neutrophils to deliver drugs to ischemic brain sites could be an optimal strategy. Since the surface of neutrophils has a formyl peptide receptor (FPR), this work modifies a nanoplatform surface by the peptide cinnamyl-F-(D)L-F-(D)L-F (CFLFLF), which can specifically bind to the FPR receptor. After intravenous injection, the fabricated nanoparticles effectively adhered to the surface of neutrophils in peripheral blood mediated by FPR, thereby hitchhiking with neutrophils to achieve higher accumulation at the inflammatory site of cerebral ischemia. In addition, the nanoparticle shell is composed of a polymer with reactive oxygen species (ROS)-responsive bond breaking and is encased in ligustrazine, a natural product with neuroprotective properties. In conclusion, the strategy of hitching the delivered drugs to neutrophils in this study could improve drug enrichment in the brain, thereby providing a general delivery platform for ischemic stroke or other inflammation-related diseases.

Indexed as

Brain IschemiaIschemic StrokeNanoparticlesReperfusion InjuryHumansInflammationNeutrophilsPyrazinesPyrazinestetramethylpyrazinecerebral ischemia-reperfusion injurydrug deliveryligustrazineneutrophilsreactive oxygen species (ROS)

Identifiers

PMID37078794
PMCPMC10323616
OpenAlexW4366463230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.