Evidence map›Paper›PMID 37078712›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2023

Breastfeeding Among People With Human Immunodeficiency Virus in North America: A Multisite Study.

Judy Levison, Jennifer McKinney, Alejandra Duque, Joanna Hawkins, Emily Ver Hoeve Bowden, Julie Dorland, Ari Bitnun, Kescha Kazmi, Douglas M Campbell, Jay MacGillivray and 13 more

Abstract readMulticenter Study
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  15. Update on HIV prevention and management in pregnancy Number 10 - 2025.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025
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  19. Breastfeeding in the United States Among Women With HIV: Con Viewpoint.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Judy LevisonDepartment of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-2431-662X
Jennifer McKinneyDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-1641-9610
Alejandra DuqueDepartment of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA.
Joanna HawkinsDepartment of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA.
Emily Ver Hoeve BowdenDepartment of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA.
Julie DorlandDepartment of Obstetrics and Gynecology, University of Texas at Austin Dell Medical School, Austin, Texas, USA.
Ari BitnunDepartment of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Canada.
Kescha KazmiDepartment of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Canada.
Douglas M CampbellDepartment of Pediatrics, University of Toronto, St. Michael's Hospital, Toronto, Canada.
Jay MacGillivrayDepartment of Obstetrics and Gynecology, University of Toronto, St. Michael's Hospital, Toronto, Canada.
Mark H YudinDepartment of Obstetrics and Gynecology, University of Toronto, St. Michael's Hospital, Toronto, Canada.
Anna PowellDepartment of Obstetrics and Gynecology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Shreetoma DattaDepartment of Obstetrics and Gynecology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Lisa AbuogiDepartment of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA.
Adriana WeinbergDepartment of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA.
Natella RakhmaninaDepartment of Pediatrics, Children's National Hospital, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.
Joanna Walsh MareuilDepartment of Pediatrics, Children's National Hospital, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.
Jane HittiDepartment of Maternal Fetal Medicine, University of Washington School of Medicine, Seattle, Washington, USA.
Isabelle BoucoiranDepartment of Obstetrics and Gynecology, University of Montreal/Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada.
Fatima KakkarDepartment of Pediatrics, University of Montreal, Montreal, Quebec, Canada.
Lisa RahangdaleDepartment of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Dominika SeidmanDepartment of Obstetrics and Gynecology, University of California San Francisco, San Francisco, California, USA.
Rebecca WidenerDepartment of Pediatrics, University of South Carolina School of Medicine, Columbia, South Carolina, USA.

Funding

Women HIV Cohort Study: HIV infection and treatment among women of reproductive ageR01HD101352 · NICHD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ALCAIDE, MARIA LUISA, GOLUB, ELIZABETH T · 2019 to 2024
$18.4M
Acceptability and feasibility of combination treatment for cervical precancer among South Africa women living with HIVR01CA250850 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHIBWESHA, CARLA J, RAHANGDALE, LISA · 2020 to 2024
$2.4M
NCI NIH HHS HHSN261201200031INCI NIH HHS HHSN261201200035CNCI NIH HHS HHSN261201200035INCI NIH HHS HHSN261201200051CNCI NIH HHS R01 CA250850NICHD NIH HHS R01 HD101352NIH HHS R01CA250850
6 · The paper itself

Abstract

backgroundIn North American countries, national guidelines have strongly recommended formula over breastmilk for people with human immunodeficiency virus (HIV) because of concern for HIV transmission. However, data from resource-limited settings suggest the risk is <1% among virally suppressed people. Information regarding breastfeeding experience in high-resource settings is lacking.

methodsA retrospective multisite study was performed for individuals with HIV who breastfed during 2014-2022 in the United States (8 sites) and Canada (3 sites). Descriptive statistics were used for data analysis.

resultsAmong the 72 cases reported, most had been diagnosed with HIV and were on antiretroviral therapy prior to the index pregnancy and had undetectable viral loads at delivery. Most commonly reported reasons for choosing to breastfeed were health benefits, community expectations, and parent-child bonding. Median duration of breastfeeding was 24 weeks (range, 1 day to 72 weeks). Regimens for infant prophylaxis and protocols for testing of infants and birthing parents varied widely among institutions. No neonatal transmissions occurred among the 94% of infants for whom results were available ≥6 weeks after weaning.

conclusionsThis study describes the largest cohort to date of people with HIV who breastfed in North America. Findings demonstrate high variability among institutions in policies, infant prophylaxis, and infant and parental testing practices. The study describes challenges in weighing the potential risks of transmission with personal and community factors. Finally, this study highlights the relatively small numbers of patients with HIV who chose to breastfeed at any 1 location, and the need for further multisite studies to identify best care practices.

Indexed as

Breast FeedingHIV InfectionsFemaleHumansInfantInfant, NewbornInfectious Disease Transmission, VerticalMilk, HumanNorth AmericaRetrospective StudiesbreastfeedingHIVinstitutional practicesprenatal care

Identifiers

PMID37078712
PMCPMC10654886

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.