Evidence map›Paper›PMID 37078667›Full record

ArticleThe Hastings Center report2023

Wrestling with Social and Behavioral Genomics: Risks, Potential Benefits, and Ethical Responsibility.

Michelle N Meyer, Paul S Appelbaum, Daniel J Benjamin, Shawneequa L Callier, Nathaniel Comfort, Dalton Conley, Jeremy Freese, Nanibaa' A Garrison, Evelynn M Hammonds, K Paige Harden and 9 more

Abstract read
In one paragraph

Article in The Hastings Center report, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  12. Science and sensitivity in the study of not having sex.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Confounding fuels misinterpretation in human genetics.Proceedings. Biological sciences · 2025
    Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Confounding Fuels Misinterpretation in Human Genetics.bioRxiv : the preprint server for biology · 2025
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Michelle N Meyer
Paul S Appelbaum
Daniel J Benjamin
Shawneequa L Callier
Nathaniel Comfort
Dalton Conley
Jeremy Freese
Nanibaa' A Garrison
Evelynn M Hammonds
K Paige Harden
Sandra Soo-Jin Lee
Alicia R Martin
Daphne Oluwaseun Martschenko
Benjamin M Neale
Rohan H C Palmer
James Tabery
Eric Turkheimer
Patrick Turley
Erik Parens

Funding

Genome-Wide Analyses of Health and Well-Being PhenotypesR01AG042568 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BENJAMIN, DANIEL J · 2015 to 2021
$2.8M
Infrastructure and Core Activities of the Social Science Genetic Association ConsortiumR24AG065184 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BENJAMIN, DANIEL J · 2019 to 2023
$1.8M
Genome-wide analysis of late-onset Alzheimer's disease using intergenerational, multi-trait, and cross-ancestry dataR00AG062787 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TURLEY, PATRICK ANSEL · 2021 to 2023
$747k
NIA NIH HHS R00 AG062787NIA NIH HHS R01 AG042568NIA NIH HHS R24 AG065184
6 · The paper itself

Abstract

In this consensus report by a diverse group of academics who conduct and/or are concerned about social and behavioral genomics (SBG) research, the authors recount the often-ugly history of scientific attempts to understand the genetic contributions to human behaviors and social outcomes. They then describe what the current science-including genomewide association studies and polygenic indexes-can and cannot tell us, as well as its risks and potential benefits. They conclude with a discussion of responsible behavior in the context of SBG research. SBG research that compares individuals within a group according to a "sensitive" phenotype requires extra attention to responsible conduct and to responsible communication about the research and its findings. SBG research (1) on sensitive phenotypes that (2) compares two or more groups defined by (a) race, (b) ethnicity, or (c) genetic ancestry (where genetic ancestry could easily be misunderstood as race or ethnicity) requires a compelling justification to be conducted, funded, or published. All authors agree that this justification at least requires a convincing argument that a study's design could yield scientifically valid results; some authors would additionally require the study to have a socially favorable risk-benefit profile.

Indexed as

CommunicationGenomicsHumansPhenotypeSocial Responsibilitybehavioral geneticsbioethicspolygenic indexpolygenic risk scoreresearch ethicssociogenomics

Identifiers

PMID37078667
PMCPMC10433733

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.