Evidence map›Paper›PMID 37078654›Full record

Trial reportGut microbes

Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial.

Hao Lai, Yunfeng Li, Yafang He, Fangyao Chen, Baibing Mi, Junqi Li, Jiawen Xie, Guoqing Ma, Jinzhao Yang, Kun Xu and 15 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  18. Gut microbiota in health and disease.Molecular biomedicine · 2026
    Review
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58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Hao LaiKey Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.ORCID 0000-0003-0277-9364
Yunfeng LiKey Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Yafang HeKey Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Fangyao ChenKey Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Baibing MiKey Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Junqi LiKey Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Jiawen XieKey Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Guoqing MaKey Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Jinzhao YangKey Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Kun XuKey Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Xia LiaoDepartment of Nutrition, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Yan YinDepartment of Gastroenterology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Junrong LiangDepartment of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Liyun KongKey Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Xinyan WangBYHEALTH Institute of Nutrition & Health, Guangzhou, China.
Zhongxia LiBYHEALTH Institute of Nutrition & Health, Guangzhou, China.
Yuan ShenKey Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Shaonong DangKey Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Lei ZhangKey Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Qian WuKey Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Lingxia ZengKey Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Lin ShiSchool of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, China.
Xuguang ZhangBYHEALTH Institute of Nutrition & Health, Guangzhou, China.
Tian TianDepartment of Nutrition, Xi'an Daxing Hospital, Xi'an, China.
Xin LiuKey Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.ORCID 0000-0001-5105-0532

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dietary fibers/probiotics may relieve constipation via optimizing gut microbiome, yet with limited trial-based evidences. We aimed to evaluate the effects of formulas with dietary fibers or probiotics on functional constipation symptoms, and to identify modulations of gut microbiota of relevance. We conducted a 4-week double-blinded randomized placebo-controlled trial in 250 adults with functional constipation. Intervention: A: polydextrose; B: psyllium husk; C: wheat bran + psyllium husk; D:

Indexed as

Bifidobacterium animalisGastrointestinal DiseasesGastrointestinal MicrobiomeProbioticsPsylliumAdultConstipationDietary FiberDouble-Blind MethodHumansRNA, Ribosomal, 16SDietary FiberPsylliumRNA, Ribosomal, 16SDietary fiberfunctional constipationgut microbiotanutritional interventionprobiotics

Identifiers

PMID37078654
PMCPMC10120550

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.