Evidence map›Paper›PMID 37078467›Full record

ArticleInfection control and hospital epidemiology2023

Implementing and validating a home-infusion central-line-associated bloodstream infection surveillance definition.

Sara C Keller, Susan M Hannum, Kimberly Weems, Opeyemi Oladapo-Shittu, Alejandra B Salinas, Jill A Marsteller, Ayse P Gurses, Eili Y Klein, Ilya Shpitser, Christopher J Crnich and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Infection control and hospital epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. CLABSIs aren't just for inpatients: the need to identify CLABSI burden among outpatients.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024
    Article
  3. Preparation of Patients for Central Venous Catheter Care in the Home: Perspectives From Health Care Personnel.American journal of medical quality : the official journal of the American College of Medical Quality
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Sara C KellerDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0001-9660-4367
Susan M HannumDepartment of Health Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.ORCID 0000-0003-1556-8021
Kimberly WeemsDepartment of Hospital Epidemiology and Infection Control, Johns Hopkins Health System, Baltimore, Maryland.ORCID 0000-0002-2108-9257
Opeyemi Oladapo-ShittuDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-9845-8647
Alejandra B SalinasDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-5673-5028
Jill A MarstellerDepartment of Health Policy & Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.ORCID 0000-0002-8458-954X
Ayse P GursesDepartment of Health Policy & Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.ORCID 0000-0001-7422-6852
Eili Y KleinDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-1304-5289
Ilya ShpitserDepartment of Computer Science, Johns Hopkins Whiting School of Engineering, Baltimore, Maryland.ORCID 0000-0003-2571-7326
Christopher J CrnichDivision of Infectious Diseases, Department of Medicine, University of Wisconsin School of Medicine, Madison, Wisconsin.ORCID 0000-0002-9320-9262
Nitin BhanotDivision of Infectious Diseases, Department of Medicine, Allegheny Health Network, Pittsburgh, Pennsylvania.ORCID 0000-0002-9505-0910
Clare RockDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Sara E CosgroveDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0001-9458-4331
Home Infusion CLABSI Prevention Collaborative
Johns Hopkins University · USAllegheny Health Network · USUniversity of Wisconsin–Madison · USVassar Brothers Medical Center · US

Funding

AHRQ HHS R01 HS027819
6 · The paper itself

Abstract

objectiveCentral-line-associated bloodstream infection (CLABSI) surveillance in home infusion therapy is necessary to track efforts to reduce infections, but a standardized, validated, and feasible definition is lacking. We tested the validity of a home-infusion CLABSI surveillance definition and the feasibility and acceptability of its implementation.

designMixed-methods study including validation of CLABSI cases and semistructured interviews with staff applying these approaches.

settingThis study was conducted in 5 large home-infusion agencies in a CLABSI prevention collaborative across 14 states and the District of Columbia.

participantsStaff performing home-infusion CLABSI surveillance.

methodsFrom May 2021 to May 2022, agencies implemented a home-infusion CLABSI surveillance definition, using 3 approaches to secondary bloodstream infections (BSIs): National Healthcare Safety Program (NHSN) criteria, modified NHSN criteria (only applying the 4 most common NHSN-defined secondary BSIs), and all home-infusion-onset bacteremia (HiOB). Data on all positive blood cultures were sent to an infection preventionist for validation. Surveillance staff underwent semistructured interviews focused on their perceptions of the definition 1 and 3-4 months after implementation.

resultsInterrater reliability scores overall ranged from κ = 0.65 for the modified NHSN criteria to κ = 0.68 for the NHSN criteria to κ = 0.72 for the HiOB criteria. For the NHSN criteria, the agency-determined rate was 0.21 per 1,000 central-line (CL) days, and the validator-determined rate was 0.20 per 1,000 CL days. Overall, implementing a standardized definition was thought to be a positive change that would be generalizable and feasible though time-consuming and labor intensive.

conclusionsThe home-infusion CLABSI surveillance definition was valid and feasible to implement.

Indexed as

BacteremiaCatheterization, Central VenousCatheter-Related InfectionsCross InfectionSepsisHumansReproducibility of Results

Identifiers

PMID37078467
PMCPMC10665867
OpenAlexW4366464170

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.