ArticleBiomedical optics express2023
Microfluidic immunosensor based on a graphene oxide functionalized double helix microfiber coupler for anti-Müllerian hormone detection.
Article in Biomedical optics express, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 16 citations in OpenAlex.
- Advancement in early diagnosis of polycystic ovary syndrome: biomarker-driven innovative diagnostic sensor.Mikrochimica acta · 2025Review
- Introduction to the feature issue: Advances in Optical Biosensors for Biomedical Applications.Biomedical optics express · 2024Article
- Humanoid-shaped WaveFlex biosensor for the detection of food contamination.Biomedical optics express · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A label-free microfluidic immunosensor based on the double helix microfiber coupler (DHMC) coated with graphene oxide (GO) was proposed for the specific detection of anti-Müllerian hormone (AMH). Two single-mode optical fibers were twisted in a parallel direction, the coning machine was used to fuse and taper them, and the high-sensitivity DHMC was obtained. To make a stable sensing environment, it was immobilized in a microfluidic chip. And then, the DHMC was modified by GO and bio-functionalized by the AMH monoclonal antibodies (anti-AMH MAbs) for the specific detection of AMH. The experimental results showed that the detection range of the immunosensor for AMH antigen solutions was 200 fg/mL∼50 µg/mL, the detection of limit (LOD) was ∼235.15 fg/mL, and the detection sensitivity and the dissociation coefficient were ∼3.518
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Registered trials
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