Evidence map›Paper›PMID 37077580›Full record

ArticleEuropean heart journal open2023

Impact of C-reactive protein levels on lipoprotein(a)-associated aortic stenosis incidence and progression.

Arnaud Girard, Emilie Gaillard, Rishi Puri, Romain Capoulade, Kwan L Chan, Audrey Paulin, Hasanga D Manikpurage, Jean Dumesnil, James W Tam, Koon K Teo and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Oxidized phospholipids in cardiovascular disease.Nature reviews. Cardiology · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 9 institutions in 5 countries.

Arnaud GirardCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, G1V 4G5, Canada.ORCID https://orcid.org/0000-0002-8219-9118
Emilie GaillardDepartment of Cardiology, Amsterdam UMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.
Rishi PuriDepartment of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, 44195, USA.
Romain CapouladeNantes Université, CNRS, INSERM, l'institut du thorax, F-44000 Nantes, 44007, France.ORCID https://orcid.org/0000-0002-7233-7409
Kwan L ChanDepartment of Medicine, University of Ottawa Heart Institute, Ottawa, ON, K1Y 4W7, Canada.
Audrey PaulinCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, G1V 4G5, Canada.
Hasanga D ManikpurageCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, G1V 4G5, Canada.
Jean DumesnilCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, G1V 4G5, Canada.
James W TamDepartment of Medicine, St. Boniface General Hospital, Winnipeg, MB, R2H 2A6, Canada.
Koon K TeoDepartment of Medicine (Cardiology), McMaster University, Hamilton, ON, L8S 4L8, Canada.
Christian CoutureCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, G1V 4G5, Canada.
Nicholas J WarehamDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, CB2 1TN, UK.
Marie-Annick ClavelCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, G1V 4G5, Canada.ORCID https://orcid.org/0000-0002-8924-740X
Erik S G StroesDepartment of Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.ORCID https://orcid.org/0000-0001-9555-6260
Patrick MathieuCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, G1V 4G5, Canada.ORCID https://orcid.org/0000-0002-3805-2004
Sébastien ThériaultCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, G1V 4G5, Canada.ORCID https://orcid.org/0000-0003-1893-8307
Sotirios TsimikasDivision of Cardiovascular Diseases, Department of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Philippe PibarotCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, G1V 4G5, Canada.ORCID https://orcid.org/0000-0002-3607-279X
S Matthijs BoekholdtDepartment of Cardiology, Amsterdam UMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.ORCID https://orcid.org/0000-0002-0861-0765
Benoit J ArsenaultCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, G1V 4G5, Canada.ORCID https://orcid.org/0000-0003-2240-8456
Institut universitaire de cardiologie et de pneumologie de Québec · CAAmsterdam University Medical Centers · NLCentre National de la Recherche Scientifique · FRCleveland Clinic · USMcMaster University · CASt. Boniface Hospital · CAUniversity of California San Diego · USUniversity of Cambridge · GBUniversity of Ottawa · CA

Funding

Medical Research Council MC_UU_00006/1
6 · The paper itself

Abstract

Aims: Elevated lipoprotein(a) [Lp(a)] levels are associated with the risk of coronary artery disease (CAD) and calcific aortic valve stenosis (CAVS). Observational studies revealed that Lp(a) and C-reactive protein (CRP) levels, a biomarker of systemic inflammation, may jointly predict CAD risk. Whether Lp(a) and CRP levels also jointly predict CAVS incidence and progression is unknown. Methods and results: We investigated the association of Lp(a) with CAVS according to CRP levels in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk study ( Conclusion: Lp(a) predicts the incidence and possibly progression of CAVS regardless of plasma CRP levels. Lowering Lp(a) levels may warrant further investigation in the prevention and treatment of CAVS, regardless of systemic inflammation.

Indexed as

Calcific aortic valve stenosisC-reactive proteinLipoprotein(a)

Identifiers

PMID37077580
PMCPMC10108885
OpenAlexW4361263473

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.