ArticleFrontiers in neurology2023
Associations between computed tomography markers of cerebral small vessel disease and hemorrhagic transformation after intravenous thrombolysis in acute ischemic stroke patients.
Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- Associations of Cerebrovascular Regulation and Arterial Stiffness With Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2023Pooled it
- A clinical and head CT-based scoring system for predicting high cerebral microbleeds burden in hypertensive patients.BMC medical imaging · 2026Observational
- Changes of fatty acid metabolism in FA 26:0, FA 22:2 and FA 24:1 are associated with leukoaraiosis in the elderly.BMC geriatrics · 2026Article
- Analysis of the impact of cerebral small vessel disease on neurological outcomes in patients with basal ganglia/corona radiata ischemic stroke treated with intravenous thrombolysis under multimodal MRI guidance.Frontiers in neurology · 2025Article
- Early identification and integrated nursing management of post-thrombolysis hemorrhagic transformation in acute ischemic stroke: a comprehensive review.Frontiers in neurology · 2025Review
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
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Abstract
Background: Hemorrhagic transformation (HT) is common among acute ischemic stroke patients after treatment with intravenous thrombolysis (IVT). We analyzed potential relationships between markers of cerebral small vessel disease (CSVD) and HT in patients after IVT. Methods: This study retrospectively analyzed computed tomography (CT) data for acute ischemic stroke patients before and after treatment with recombinant tissue plasminogen activator at a large Chinese hospital between July 2014 and June 2021. Total CSVD score were summed by individual CSVD markers including leukoaraiosis, brain atrophy and lacune. Binary regression analysis was used to explore whether CSVD markers were related to HT as the primary outcome or to symptomatic intracranial hemorrhage (sICH) as a secondary outcome. Results: A total of 397 AIS patients treated with IVT were screened for inclusion in this study. Patients with missing laboratory data ( Conclusion: In patients with acute ischemic stroke, severe leukoaraiosis, brain atrophy and total CSVD burden may be risk factors for HT after IVT. These findings may help improve efforts to mitigate or even prevent HT in vulnerable patients.
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