ArticleERJ open research2023
Endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lesions: safety, feasibility and diagnostic yield - experience in 50 cases.
Article in ERJ open research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Pooled it
- Ultrasound-guided transbronchial cryobiopsy of mediastinal and hilar lesions: a multicenter pragmatic cohort study with real-world evidence.BMJ open respiratory research · 2024Trial
- Enhancing Diagnostic Yield: The Role of Endobronchial Ultrasound-Guided Cryobiopsy in the Evaluation of Mediastinal Lymphadenopathy.CHEST pulmonary · 2026Article
- Cryobiopsy Outperforms Fine-Needle Aspiration for Mediastinal Lymphadenopathy: A Within-Patient Diagnostic Accuracy Study and Clinical Predictors of Success.Journal of clinical medicine · 2026Article
- Diagnostic value of EBUS-guided transbronchial mediastinal cryobiopsyERJ open research · 2026Article
- Confocal laser endomicroscopy-assisted endobronchial ultrasound-guided needle aspiration in diagnosing mediastinal and/or hilar lymphadenopathy (COLLABORATION-III): protocol for a randomised controlled trial.BMJ open respiratory research · 2026Article
- Superior Diagnostic Yield of EBUS-Guided Cryobiopsy over Needle Aspiration in Isolated, Mass-Negative Mediastinal Lymphadenopathy: A Prospective Within-Patient Study.Diagnostics (Basel, Switzerland) · 2026Article
- Molecular Analysis of EBUS-TBNA Samples for Nodal Staging in Non-Small Cell Lung Cancer.Cancers · 2026Review
- Comparative Efficacy of Transbronchial Needle Aspiration and Cryobiopsies in Thoracic Disorders: A Systematic Review and Meta-Analysis for Optimal Diagnostic Efficacy.Life (Basel, Switzerland) · 2026Review
- Diagnostic yield and histopathological assessment of endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy: a prospective comparison of two tunnelling approaches.ERJ open research · 2026Article
- Case report: Tumor-like mediastinal tuberculous lymphadenitis with paravertebral cold abscess under cumulative immunosuppression: a case highlighting altered host-pathogen interactions.Frontiers in immunology · 2026Article
- Transbronchial Mediastinal Cryobiopsy in Diagnosing Sarcoidosis: A Three-Case Report.Internal medicine (Tokyo, Japan) · 2025Article
- In-channel cryoprobe extraction for mediastinal and transbronchial cryobiopsy: a novel technique (cross-sectional study).Annals of medicine and surgery (2012) · 2025Article
- Transbronchial Mediastinal Cryobiopsy Guided by Endobronchial Ultrasound in Addition to Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in the Diagnosis of Ilo-Mediastinal Lymphadenopathy Without Obvious Primary Lung Neoplastic Lesion: A Prospective Multicenter Study.Journal of clinical medicine · 2025Article
- The diagnostic accuracy of lymph node silicosis for pulmonary silicosis in South African gold miners.ERJ open research · 2025Article
- Enhancing diagnostic precision: a multicentric study of endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy in lymphoproliferative disorders.ERJ open research · 2025Article
- [DGP and ÖGP Congress 2024: Highlights from Interventional Pulmonology].Pneumologie (Stuttgart, Germany) · 2025Article
- Article
- Transbronchial Mediastinal Cryobiopsy Diagnostic Yield and Perioperative Patient Management: A Single Tertiary Center Experience.Thoracic research and practice · 2025Article
- EBUS guided trans-esophgeal cryobiopsy-two case reports.Lung India : official organ of Indian Chest Society · 2025Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the technique of choice in the study of mediastinal and hilar lesions; however, it can be affected by the insufficiency of intact biopsy samples, which might decrease its diagnostic yield for certain conditions, thus requiring re-biopsies or additional diagnostic procedures such as mediastinoscopy when the probability of malignancy remains high. Our objectives were to 1) attempt to reproduce this technique in the same conditions that we performed EBUS-TBNA, Methods: This was a prospective study of 50 patients who underwent EBUS-TBNA and EBUS-guided transbronchial mediastinal cryobiopsy (TMC) in a single procedure using a 22-G TBNA needle and a 1.1-mm cryoprobe subsequently between January and August 2022. Patients with mediastinal lesions >1 cm were recruited, and EBUS-TBNA and TMC were performed in the same lymph node station. Results: The diagnostic yield was 82% and 96% for TBNA and TMC, respectively. Diagnostic yields were similar for sarcoidosis, while cryobiopsy was more sensitive than TBNA in lymphomas and metastatic lymph nodes. As for complications, there was no pneumothorax and in no case was there significant bleeding. There were no complications during the procedure or in the follow-up of these patients. Conclusions: TMC following our method is a minimally invasive, rapid and safe technique that can be performed in a bronchoscopy suite under moderate sedation, with a higher diagnostic yield than EBUS-TBNA, especially in cases of lymphoproliferative disorders and metastatic lymph nodes or when more biopsy sample is needed for molecular determinations.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.