ReviewACS medicinal chemistry letters2023
Accelerating Drug Discovery: Synthesis of Complex Chemotypes via Multicomponent Reactions.
Review in ACS medicinal chemistry letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Discovery of Novel Synthetic Cyclohexene-Based Small Molecules Targeting Senescence against Age-Related Pulmonary Fibrosis.Journal of medicinal chemistry · 2026Article
- Multicomponent reactions for protein tyrosine phosphatase inhibitors.Molecular diversity · 2026Review
- Decarboxylative carbonyl alkylative amination: A general and practical strategy for aliphatic amine synthesis.Science advances · 2026Article
- Generating multimillion chemical space based on the Ugi four-center three-component reaction with oxocarboxylic acids.Molecular diversity · 2026Article
- A mild and atom-efficient four-component cascade strategy for the construction of biologically relevant 4-hydroxyquinolin-2(1Beilstein journal of organic chemistry · 2026Article
- One-pot Synthesis of Functionalized Benzimidazole-quinazolinone Derivatives.Current organic synthesis · 2026Article
- Recent advances in synthesis and medicinal chemistry of pyrrolodiazepines.Frontiers in chemistry · 2026Review
- A copper-doped ZIF-8: a high-performance catalyst for eco-friendly Ullmann and Biginelli reactions.Scientific reports · 2025Article
- Triazine Macrocycle Libraries: Synthesis, logD Prediction, and a Surprisingly Hydrophobic, Membrane-Permeable Diamine.ACS medicinal chemistry letters · 2025Article
- Strong Hydrogen Bond Donating Solvents Accelerate the Passerini Three-Component Reaction.The Journal of organic chemistry · 2025Article
- Article
- Multicomponent reactions (MCRs) yielding medicinally relevant rings: a recent update and chemical space analysis of the scaffolds.RSC advances · 2025Review
- α-Ketoglutaric acid in Ugi reactions and Ugi/aza-Wittig tandem reactions.Beilstein journal of organic chemistry · 2025Article
- Isocyanate-based multicomponent reactions.RSC advances · 2024Review
- Accessing Promising Passerini Adducts in Anticancer Drug Design.Molecules (Basel, Switzerland) · 2024Article
- Discovery of CRBN-Dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library.Journal of the American Chemical Society · 2024Article
- Metallaphotocatalytic triple couplings for modular synthesis of elaborate N-trifluoroalkyl anilines.Nature communications · 2024Article
- Recent trends for chemoselectivity modulation in one-pot organic transformations.RSC advances · 2024Review
- Allostery Illuminated: Harnessing AI and Machine Learning for Drug Discovery.ACS medicinal chemistry letters · 2024Review
- A General Three-Component Alkyl Petasis Boron-Mannich Reaction.Journal of the American Chemical Society · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The generation of multiple bonds in one reaction step has attracted massive interest in drug discovery and development. Multicomponent reactions (MCRs) offer the advantage of combining three or more reagents in a one-pot fashion to effectively yield a synthetic product. This approach significantly accelerates the synthesis of relevant compounds for biological testing. However, there is a perception that this methodology will only produce simple chemical scaffolds with limited use in medicinal chemistry. In this Microperspective, we want to highlight the value of MCRs toward the synthesis of complex molecules characterized by the presence of quaternary and chiral centers. This paper will cover specific examples showing the impact of this technology toward the discovery of clinical compounds and recent breakthroughs to expand the scope of the reactions toward topologically rich molecular chemotypes.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.