SynthesisBMC medicine2023
Genome-wide association analyses identified novel susceptibility loci for pulmonary embolism among Han Chinese population.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in BMC medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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35citing papers in PubMed, 1 pooled it
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
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- Genetic and biological determinants of pulmonary embolism: Insights from Mendelian randomization studies.World journal of experimental medicine · 2026Review
- Causal association between lipid profile and mental disorders: evidence from a bidirectional Mendelian randomization study.European archives of psychiatry and clinical neuroscience · 2026Article
- Association between metabolic score for visceral fat and adverse outcomes in chronic obstructive pulmonary disease.BMJ open respiratory research · 2026Article
- Population-specific ABO haplotypes reveal distinct venous thromboembolism risk in East Asians: insights from a large-scale genetic study.The Lancet regional health. Western Pacific · 2026Article
- Partially connected neural networks for complex trait prediction: application to human height.Human genetics · 2025Article
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- A Self-Adapting Polygenic Risk Score Model Improves Risk Prediction of Venous Thromboembolism in Han Chinese Cohorts.Phenomics (Cham, Switzerland) · 2025Article
- Estimated Glomerular Filtration Rate Decline is Causally Associated with Acute Pulmonary Embolism: A Nested Case-Control and Mendelian Randomization Study.Thrombosis and haemostasis · 2025Article
- Thrombotic risk determined byResearch and practice in thrombosis and haemostasis · 2025Article
- Whole genome sequencing identifies pathogenic genetic variants in Han Chinese patients with familial venous thromboembolism.Communications biology · 2025Article
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- Exploring the Causal Link Between Plasma Lipidome and Trigeminal Neuralgia Using Bidirectional Mendelian Randomization.Pain research & management · 2025Article
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- Causal relationship between circulating plasma lipids and atopic dermatitis risk: potential drug targets and therapeutic strategies.Archives of dermatological research · 2024Article
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Corrections and comments
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Authors and funding
49 authors at 20 institutions in 2 countries.
Zhu Zhang *Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital; National Center for Respiratory Medicine; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; National Clinical Research Center for Respiratory Diseases, Beijing, 100029, China.
Haobo Li *China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital; National Center for Respiratory Medicine; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; National Clinical Research Center for Respiratory Diseases, Beijing, 100029, China.
Haoyi Weng *Shenzhen WeGene Clinical Laboratory; WeGene, Shenzhen Zaozhidao Technology Co. Ltd; Hunan Provincial Key Lab On Bioinformatics, School of Computer Science and Engineering, Central South University, Shenzhen, 518042, China.
Geyu Zhou *Department of Bioinformatics and Biostatistics, SJTU-Yale Joint Center for Biostatistics, College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Hong Chen *Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Guoru YangDepartment of Pulmonary and Critical Care Medicine, Weifang No.2 People's Hospital, Weifang, 261021, China.
Ping ZhangDepartment of Pulmonary and Critical Care Medicine, Dongguan People's Hospital, Dongguan, 523059, China.
Xiangyan ZhangDepartment of Pulmonary and Critical Care Medicine, Guizhou Provincial People's Hospital, Guiyang, 550002, China.
Yingqun JiDepartment of Pulmonary and Critical Care Medicine, Shanghai East Hospital Affiliated by Tongji University, Shanghai, 200120, China.
Kejing YingDepartment of Respiratory Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310020, China.
Bo LiuDepartment of Pulmonary and Critical Care Medicine, Department of Clinical Microbiology, Zibo City Key Laboratory of Respiratory Infection and Clinical Microbiology, Linzi District People's Hospital, Zibo, 255400, China.
Qixia XuDepartment of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of University of Science and Technology of China, Hefei, 230001, China.
Yongjun TangDepartment of Pulmonary and Critical Care Medicine, Xiangya Hospital Central South University, Changsha, 410008, China.
Guangfa ZhuDepartment of Pulmonary and Critical Care, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Zhihong LiuFuwai Hospital, Chinese Academy of Medical Science; National Center for Cardiovascular Diseases, Beijing, 100037, China.
Shuyue XiaDepartment of Pulmonary and Critical Care Medicine, Central Hospital Affiliated to Shenyang Medical College, Shenyang, 110001, China.
Xiaohong YangDepartment of Pulmonary and Critical Care Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang, 830001, China.
Lixia DongDepartment of Pulmonary and Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin, 300050, China.
Ling ZhuDepartment of Pulmonary and Critical Care Medicine, Shandong Provincial Hospital, Jinan, 250021, China.
Mian ZengDepartment of Medical Intensive Care Unit, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
Yadong YuanDepartment of Pulmonary and Critical Care Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, 050004, China.
Yuanhua YangDepartment of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100026, China.
Nuofu ZhangState Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510230, China.
Xiaomao XuDepartment of Pulmonary and Critical Care Medicine, Beijing Hospital, Beijing, 100080, China.
Wenyi PangDepartment of Pulmonary and Critical Care Medicine, Beijing Jishuitan Hospital, Beijing, 100035, China.
Meng ZhangDepartment of Pulmonary and Critical Care, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Yu ZhangChina-Japan Friendship Hospital, Capital Medical University; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital; National Center for Respiratory Medicine; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; National Clinical Research Center for Respiratory Diseases, Beijing, 100029, China.
Kaiyuan ZhenInstitute of Clinical Medical Sciences, China-Japan Friendship Hospital; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital; National Center for Respiratory Medicine; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; National Clinical Research Center for Respiratory Diseases, Beijing, 100029, China.
Dingyi WangInstitute of Clinical Medical Sciences, China-Japan Friendship Hospital; National Center for Respiratory Medicine; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; National Clinical Research Center for Respiratory Diseases, Beijing, China, 100029.
Jieping LeiInstitute of Clinical Medical Sciences, China-Japan Friendship Hospital; National Center for Respiratory Medicine; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; National Clinical Research Center for Respiratory Diseases, Beijing, China, 100029.
Sinan WuInstitute of Clinical Medical Sciences, China-Japan Friendship Hospital; National Center for Respiratory Medicine; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; National Clinical Research Center for Respiratory Diseases, Beijing, China, 100029.
Shi ShuDepartment of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital; National Center for Respiratory Medicine; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; National Clinical Research Center for Respiratory Diseases, Beijing, 100029, China.
Yunxia ZhangDepartment of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital; National Center for Respiratory Medicine; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; National Clinical Research Center for Respiratory Diseases, Beijing, 100029, China.
Shuai ZhangDepartment of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital; National Center for Respiratory Medicine; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; National Clinical Research Center for Respiratory Diseases, Beijing, 100029, China.
Qian GaoDepartment of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital; National Center for Respiratory Medicine; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; National Clinical Research Center for Respiratory Diseases, Beijing, 100029, China.
Qiang HuangDepartment of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital; National Center for Respiratory Medicine; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; National Clinical Research Center for Respiratory Diseases, Beijing, 100029, China.
Chao DengDepartment of Bioinformatics and Biostatistics, SJTU-Yale Joint Center for Biostatistics, College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Xi FuShenzhen WeGene Clinical Laboratory; WeGene, Shenzhen Zaozhidao Technology Co. Ltd; Hunan Provincial Key Lab On Bioinformatics, School of Computer Science and Engineering, Central South University, Shenzhen, 518042, China.
Gang ChenShenzhen WeGene Clinical Laboratory; WeGene, Shenzhen Zaozhidao Technology Co. Ltd; Hunan Provincial Key Lab On Bioinformatics, School of Computer Science and Engineering, Central South University, Shenzhen, 518042, China.
Wenxin DuanInstitute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China.
Jun WanDepartment of Pulmonary and Critical Care, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Wanmu XieDepartment of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital; National Center for Respiratory Medicine; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; National Clinical Research Center for Respiratory Diseases, Beijing, 100029, China.
Peng ZhangBeijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Shengfeng WangDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China.
Peiran YangInstitute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China.
Xianbo Zuo *Department of Dermatology, China-Japan Friendship Hospital, Beijing, China; Department of Pharmacy, China-Japan Friendship Hospital, No. 2, East Yinghua Road, Chaoyang District, Beijing, 100029, China. zuoxianbo@qq.com.
Zhenguo Zhai *Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital; National Center for Respiratory Medicine; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; National Clinical Research Center for Respiratory Diseases, Beijing, 100029, China. zhaizhenguo2011@126.com.
Chen Wang *Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China. wangchen@pumc.edu.cn.
China pUlmonary Thromboembolism REgistry Study (CURES) investigators
Academy of Medical Sciences · GBCapital Medical University · CNCentral South University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNPeking University · CNShanghai Jiao Tong University · CNBeijing Hospital · CNCentral Hospital Affiliated to Shenyang Medical College · CNChina-Japan Friendship Hospital · CNFirst Affiliated Hospital of Guangzhou Medical University · CNGuizhou Provincial People's Hospital · CNHebei Medical University · CNLinzi District People's Hospital · CNPeople's Hospital of Xinjiang Uygur Autonomous Region · CNShandong Provincial Hospital · CNShanghai East Hospital · CNSir Run Run Shaw Hospital · CNSun Yat-sen University · CNThe Affiliated Yongchuan Hospital of Chongqing Medical University · CNTianjin Medical University General Hospital · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA large proportion of pulmonary embolism (PE) heritability remains unexplained, particularly among the East Asian (EAS) population. Our study aims to expand the genetic architecture of PE and reveal more genetic determinants in Han Chinese.
methodsWe conducted the first genome-wide association study (GWAS) of PE in Han Chinese, then performed the GWAS meta-analysis based on the discovery and replication stages. To validate the effect of the risk allele, qPCR and Western blotting experiments were used to investigate possible changes in gene expression. Mendelian randomization (MR) analysis was employed to implicate pathogenic mechanisms, and a polygenic risk score (PRS) for PE risk prediction was generated.
resultsAfter meta-analysis of the discovery dataset (622 cases, 8853 controls) and replication dataset (646 cases, 8810 controls), GWAS identified 3 independent loci associated with PE, including the reported loci FGG rs2066865 (p-value = 3.81 × 10
conclusionsWe identified FABP2, related to the transport of long-chain fatty acids, contributing to the risk of PE and provided more evidence for the essential role of metabolic pathways in PE development.
Indexed as
East Asian PeopleGenetic Predisposition to DiseaseGenome-Wide Association StudyPulmonary EmbolismABO Blood-Group SystemChinaFatty Acid-Binding ProteinsFibrinogenGalactosyltransferasesGenotypeHumansPolymorphism, Single NucleotideRisk FactorsABO Blood-Group SystemABO protein, humanFABP2 protein, humanFatty Acid-Binding ProteinsFGG protein, humanFibrinogenGalactosyltransferasesGWASHan ChinesePulmonary embolism
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