Evidence map›Paper›PMID 37076866›Full record

ArticleBMC ophthalmology2023

Mechanical protective effect of lens anterior capsule disc on corneal endothelial cells during femtosecond laser-assisted cataract surgery in a rabbit model.

Bowen Wu, Xue Ding, Shaowei Li, Dongmei Huo, Fan Zhang, Weiyan Liang, Ling Li, Zexia Dou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Bowen Wu *Aier School of Ophthalmology, Central South University, No.932, Lushan South Road, Changsha, Hunan province, China.
Xue Ding *Beijing Aier-Intech Eye Hospital, Beijing, China.
Shaowei LiAier School of Ophthalmology, Central South University, No.932, Lushan South Road, Changsha, Hunan province, China. lishaowei@csu.edu.cn.
Dongmei HuoBeijing Aier-Intech Eye Hospital, Beijing, China.
Fan ZhangAier School of Ophthalmology, Central South University, No.932, Lushan South Road, Changsha, Hunan province, China.
Weiyan LiangTianjin University Aier Eye Hospital, Tianjin, China.
Ling LiBeijing Aier-Intech Eye Hospital, Beijing, China.
Zexia DouBeijing Aier-Intech Eye Hospital, Beijing, China.
Central South University · CNTianjin Medical University · CN

Funding

A research grant from Alcon GDO-20200414-0001
6 · The paper itself

Abstract

purposeTo evaluate the effects of a novel technique using an isolated lens anterior capsule disc (LACD) to protect corneal endothelial cells in rabbit eyes during femtosecond laser-assisted cataract surgery.

methodsExperimental study. 40 rabbits were divided into endothelium-protected (experimental) and control groups, with 20 rabbits in each group. In the experimental group, after femtosecond laser capsulotomy, the isolated capsule disc was lifted to the corneal endothelium by an ophthalmic viscosurgical device. The endothelium was damaged for 1 min with an ultrasonic probe. The control group underwent the same surgery, except that the disc was removed immediately after capsulorhexis. Corneal endothelioscopy was performed preoperatively and on postoperative days (PODs) 3 and 7 to observe endothelial cell counts (ECC) and endothelial cell loss rate. Central corneal thickness (CCT) was measured before and at PODs 1, 3 and 7.

resultsThere were 3.59%±1.88% (p < 0.001) and 2.92%±2.14% (p < 0.001) loss of ECC in experimental group at POD3 and POD7, respectively, while those in the control group were 11.62%±7.43% and 10.34%±5.77%, respectively. On POD 1, the difference in central corneal thickness was significant(P = 0.019) between the two groups. At POD 3 and POD 7, CCT was not significantly different (P = 0.597;0.913) between the two groups.

conclusionsThe isolated LACD technique significantly reduced damage to the endothelium caused by ultrasonic energy and protects corneal endothelial cells during phacoemulsification.

Indexed as

CataractCataract ExtractionLaser TherapyLens Implantation, IntraocularPhacoemulsificationAnimalsCorneaEndothelial CellsEndothelium, CornealLasersProspective StudiesRabbitsCorneal endothelial cellEndothelial cell lossIsolated capsulotomy disc techniquelens anterior capsule disc, femtosecond laser-assisted cataract surgeryOphthalmic viscoelastic devicesPhacoemulsification

Identifiers

PMID37076866
PMCPMC10114485
OpenAlexW4366415336

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.