Evidence map›Paper›PMID 37076678›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2023

Imaging Brown Adipose Tissue with TSPO PET Tracers in Preclinical Animal Studies.

Biyue Zhu, Steven H Liang, Chongzhao Ran

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Biyue ZhuMolecular Imaging Laboratory, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Steven H LiangDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Chongzhao RanMolecular Imaging Laboratory, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA. CRAN@mgh.harvard.edu.
Harvard University · USAthinoula A. Martinos Center for Biomedical Imaging · US

Funding

Near infrared fluorescence imaging of reactive oxygen species in Alzheimer's diseaseR01AG055413 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI RAN, CHONGZHAO · 2018 to 2022
$2.1M
Near infrared Fluorescence Ocular Imaging of Soluble Amyloid Beta SpeciesR21AG059134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI RAN, CHONGZHAO · 2018 to 2019
$459k
NIA NIH HHS R01 AG055413NIA NIH HHS R21 AG059134
6 · The paper itself

Abstract

Brown adipose tissue (BAT) is closely associated with thermogenesis and related to numerous diseases, including type 2 diabetes, nonalcoholic fatty liver disease (NAFLD), and obesity. Using molecular imaging technologies to monitor BAT could facilitate etiology elucidation, disease diagnosis, and therapeutics development. Translocator protein (TSPO), an 18 kDa protein that mainly locates on the outer mitochondrial membrane, has been proven as a promising biomarker for monitoring BAT mass. Here, we lay out the steps for imaging BAT with TSPO PET tracer [

Indexed as

Adipose Tissue, BrownDiabetes Mellitus, Type 2AnimalsAnimals, LaboratoryCarrier ProteinsMicePositron-Emission TomographyCarrier ProteinsBrown adipose tissue (BAT)Positron emission tomography (PET)Translocator protein (TSPO)

Identifiers

PMID37076678
OpenAlexW4366403801

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.