Evidence map›Paper›PMID 37076675›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2023

Thermogenic Phenotyping in Mice.

Donghua Hu, Irfan J Lodhi

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.7field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Donghua HuDivision of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. hudonghua@wustl.edu.
Irfan J LodhiDivision of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Diabetes Australia · AUWashington University in St. Louis · US

Funding

WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Jennifer Lynn Powers Carson · 2013 to 2026
$27.1M
Mitochondrial dynamics and the control of adipose tissue thermogenesisR01DK132239 · NIDDK · WASHINGTON UNIVERSITY · PI Irfan J Lodhi · 2022 to 2026
$1.9M
REGULATION OF ADIPOSE TISSUE REMODELING AND ENERGY HOMEOSTASISR01DK115867 · NIDDK · WASHINGTON UNIVERSITY · PI LODHI, IRFAN J · 2018 to 2022
$1.9M
Metabolic Link Between Peroxisomes and Mitochondria in the Regulation of ThermogenesisR01DK118333 · NIDDK · WASHINGTON UNIVERSITY · PI LODHI, IRFAN J · 2019 to 2021
$1.2M
NIDDK NIH HHS P30 DK020579NIDDK NIH HHS R01 DK115867NIDDK NIH HHS R01 DK118333NIDDK NIH HHS R01 DK132239
6 · The paper itself

Abstract

Thermogenesis mediated by brown adipose tissue (BAT) and brown-like fat plays an important role in regulating metabolic homeostasis in mammals. Accurate measurement of metabolic responses to brown fat activation, including heat generation and increased energy expenditure is essential for characterizing thermogenic phenotypes in preclinical studies. Here, we describe two methods for assessing thermogenic phenotypes in mice under non-basal states. First, we describe a protocol for measuring body temperature in cold-treated mice using implantable temperature transponders, which allow for continuous monitoring of body temperature. Second, we describe a method for using indirect calorimetry to measure β3-adrenergic agonist-stimulated changes in oxygen consumption, a proxy for thermogenic fat activation.

Indexed as

Adipose Tissue, BrownThermogenesisAnimalsBody TemperatureCold TemperatureEnergy MetabolismMammalsMiceMice, Inbred C57BLMice, KnockoutTemperatureBody temperatureEnergy expenditureIndirect calorimetryMetabolic cagesOxygen consumptionThermogenesis

Identifiers

PMID37076675
OpenAlexW4366403204

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.