ArticleScientific reports2023
Qualitative study on diabetic cutaneous wound healing with radiation crosslinked bilayer collagen scaffold in rat model.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Single-cell transcriptomics-guided dynamic hydrogel delivery of artemisia argyi-derived EVs relieves ER stress and promotes diabetic wound regeneration.Journal of nanobiotechnology · 2026Article
- ONX-0914 Alleviates Impaired Diabetic Wound Healing by Restoring Redox Homeostasis and Modulating Pro-Inflammatory Response.Medicina (Kaunas, Lithuania) · 2026Article
- Bio-enhanced silk fibroin-based scaffolds for chronic diabetic foot ulcers.Burns & trauma · 2026Review
- Repurposing amlexanox as a topical anti-inflammatory and antioxidant intervention for diabetic foot ulcers: insights from in-silico and in-vivo studies.Inflammopharmacology · 2026Article
- Evaluation of wound regeneration potential of nano-phytoextracts loaded carboxymethyl chitosan scaffolds for diabetic foot ulcer.Scientific reports · 2025Article
- Current Insights and Future Directions in Scar Management and Skin Regeneration.International journal of molecular sciences · 2025Review
- Radiation cross-linked collagen scaffolds facilitate root coverage and keratinized gingival regeneration.Bioactive materials · 2025Article
- A multifunctional hydrogel loaded with magnesium-doped bioactive glass-induced vesicle clusters enhances diabetic wound healing by promoting intracellular delivery of extracellular vesicles.Bioactive materials · 2025Article
- The effect of chitosan/alginate hydrogel loaded quercetin on wound healing in diabetic rat model.Journal of molecular histology · 2025Article
- Alternative therapeutic strategies in diabetes management.World journal of diabetes · 2024Review
- Scaffold-Mediated Drug Delivery for Enhanced Wound Healing: A Review.AAPS PharmSciTech · 2024Review
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Authors and funding
6 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Diabetes may leave patients more prone to skin problems, and minor skin conditions can more easily turn into serious damage to the extracellular matrix, which further impairs the skin's mechanical properties and delays wound healing. Therefore, the aim of the work is to develop extracellular matrix substitution to remodel the mechanical properties of diabetic cutaneous wound and thus accelerate diabetic wound healing. A green fabrication approach was used to prepare radiation crosslinked bilayer collagen scaffold from collagen dispersion. The morphological, mechanical and swelling characteristics of radiation crosslinked bilayer collagen scaffold were assessed to be suitable for cutaneous wound remodeling. The feasibility of radiation crosslinked bilayer collagen scaffold was performed on full-skin defect of streptozotocin-induced diabetic rats. The tissue specimens were harvested after 7, 14, and 21 days. Histopathological analysis showed that radiation crosslinked bilayer collagen scaffold has beneficial effects on inducing skin regeneration and remodeling in diabetic rats. In addition, immunohistochemical staining further revealed that the radiation crosslinked bilayer collagen scaffold could not only significantly accelerate the diabetic wound healing, but also promote angiogenesis factor (CD31) production. Vascularization was observed as early as day 7. The work expands the therapeutic ideas for cutaneous wound healing in diabetes.
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