ArticleJournal of cardiovascular computed tomography
Endothelial shear stress computed from coronary computed tomography angiography: A direct comparison to intravascular ultrasound.
Article in Journal of cardiovascular computed tomography. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Advanced quantitative CT for coronary artery disease: integrating stenosis quantification, plaque quantification, and fractional flow reserve-CT.The British journal of radiology · 2026Review
- Hemodynamic Study of Plaque Progression and Regression Based on Coronary CTA Imaging using Computational Fluid Dynamics Method: Preliminary Results.Journal of cardiovascular translational research · 2026Article
- The GRK2/AP-1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Cardiovascular computed tomography in cardiovascular disease: An overview of its applications from diagnosis to prediction.Journal of geriatric cardiology : JGC · 2024Article
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Authors and funding
18 authors.
Funding
Abstract
introductionIntravascular ultrasound (IVUS) studies have shown that biomechanical variables, particularly endothelial shear stress (ESS), add synergistic prognostic insight when combined with anatomic high-risk plaque features. Non-invasive risk assessment of coronary plaques with coronary computed tomography angiography (CCTA) would be helpful to enable broad population risk-screening.
aimTo compare the accuracy of ESS computation of local ESS metrics by CCTA vs IVUS imaging.
methodsWe analyzed 59 patients from a registry of patients who underwent both IVUS and CCTA for suspected CAD. CCTA images were acquired using either a 64- or 256-slice scanner. Lumen, vessel, and plaque areas were segmented from both IVUS and CCTA (59 arteries, 686 3-mm segments). Images were co-registered and used to generate a 3-D arterial reconstruction, and local ESS distribution was assessed by computational fluid dynamics (CFD) and reported in consecutive 3-mm segments.
resultsAnatomical plaque characteristics (vessel, lumen, plaque area and minimal luminal area [MLA] per artery) were correlated when measured with IVUS and CCTA: 12.7 ± 4.3 vs 10.7 ± 4.5 mm
conclusionLocal ESS evaluation by CCTA is possible and similar to IVUS; and is useful for identifying local flow patterns that are relevant to plaque development, progression, and destabilization.
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