Evidence map›Paper›PMID 37076146›Full record

ArticleBMJ open2023

Exploring gender dysphoria and related outcomes in a prospective cohort study: protocol for the Swedish Gender Dysphoria Study (SKDS).

Fatih Özel, Malin Indremo, Georgios Karamanis, Ulf Elofsson, Ulrika Beckman, Attila Fazekas, Louise Frisén, Magnus Isaksson, Lotta Sandström, Nils Thelin and 5 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 2 countries.

Fatih ÖzelDepartment of Organismal Biology, Uppsala University, Uppsala, Sweden.
Malin IndremoDepartment of Medical Sciences, Psychiatry, Uppsala University, Uppsala, Sweden.
Georgios KaramanisDepartment of Medical Sciences, Psychiatry, Uppsala University, Uppsala, Sweden.
Ulf ElofssonDepartment of Medical Sciences, Psychiatry, Uppsala University, Uppsala, Sweden.
Ulrika BeckmanDepartment of Psychiatry, Sahlgrenska University Hospital, Gothenburg, Sweden.
Attila FazekasDepartment of Psychiatry, Lund University, Lund, Sweden.
Louise FrisénDepartment of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
Magnus IsakssonDepartment of Medical Sciences, Endocrinology and Mineral Metabolism, Uppsala University, Uppsala, Sweden.
Lotta SandströmANOVA, Andrology, Sexual Medicine and Transgender Medicine, Karolinska University Hospital, Stockholm, Sweden.
Nils ThelinDepartment of Psychiatry, Linköping University Hospital, Linköping, Sweden.
Åsa TivestenWallenberg Laboratory for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Jeanette WahlbergDepartment of Endocrinology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Alkistis SkalkidouDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Owe BodlundDepartment of Clinical Sciences, Psychiatry, Umeå Universitet, Umeå, Sweden.
Fotios C PapadopoulosDepartment of Medical Sciences, Psychiatry, Uppsala University, Uppsala, Sweden fotis.papadopoulos@neuro.uu.se.ORCID 0000-0002-8692-3652
Uppsala University · SEKarolinska Institutet · SEKarolinska University Hospital · SELinköping University Hospital · SELund University · SENational Academy of Medicine · USÖrebro University · SESahlgrenska University Hospital · SEUmeå University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThere has been a drastic increase in the reported number of people seeking help for gender dysphoria in many countries over the last two decades. Yet, our knowledge of gender dysphoria and related outcomes is restricted due to the lack of high-quality studies employing comprehensive approaches. This longitudinal study aims to enhance our knowledge of gender dysphoria; different aspects will be scrutinised, focusing primarily on the psychosocial and mental health outcomes, prognostic markers and, secondarily, on the underlying mechanisms for its origin. METHODS AND ANALYSIS: The Swedish Gender Dysphoria Study is an ongoing multicentre longitudinal cohort study with 501 registered participants with gender dysphoria who are 15 years old or older. Participants at different phases of their clinical evaluation process can enter the study, and the expected follow-up duration is three years. The study also includes a comparison group of 458 age- and county-matched individuals without gender dysphoria. Data on the core outcomes of the study, which are gender incongruence and experienced gender dysphoria, body satisfaction and satisfaction with gender-affirming treatments, as well as other relevant outcomes, including mental health, social functioning and life satisfaction, are collected via web surveys. Two different research visits, before and after starting on gender-affirming hormonal treatment (if applicable), are planned to collect respective biological and cognitive measures. Data analysis will be performed using appropriate biostatistical methods. A power analysis showed that the current sample size is big enough to analyse continuous and categorical outcomes, and participant recruitment will continue until December 2022. ETHICS AND DISSEMINATION: The ethical permission for this study was obtained from the Local Ethical Review Board in Uppsala, Sweden. Results of the study will be presented at national and international conferences and published in peer-reviewed journals. Dissemination will also be implemented through the Swedish Gender Dysphoria Study network in Sweden.

Indexed as

Gender DysphoriaTransgender PersonsAdolescentFemaleGender IdentityHumansLongitudinal StudiesMaleProspective StudiesSwedenAdult psychiatryChild & adolescent psychiatryEPIDEMIOLOGY

Identifiers

PMID37076146
PMCPMC10124297
OpenAlexW4366393881

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.