ArticleCortex; a journal devoted to the study of the nervous system and behavior2023
Thinking versus feeling: How interoception and cognition influence emotion recognition in behavioural-variant frontotemporal dementia, Alzheimer's disease, and Parkinson's disease.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Social cognition in Parkinson's disease: a comprehensive systematic review and integrative conceptual framework.Frontiers in aging neuroscience · 2026Pooled it
- Neuroimaging Meta-Analyses Reveal Convergence of Interoception, Emotion, and Social Cognition Across Neurodegenerative Diseases.Biological psychiatry · 2025Pooled it
- From Breath to Behavior: Respiratory Features Predict Visual Detection Performance.bioRxiv : the preprint server for biology · 2026Article
- Prefrontal dysregulation of interoceptive and emotional processing in episodic migraine: a task-based fMRI study.The journal of headache and pain · 2026Article
- Connectome-based markers predict the sub-types of frontotemporal dementia.Molecular psychiatry · 2026Article
- Cardiovascular risk factors and the allostatic interoceptive network in dementia.Cardiovascular research · 2025Article
- Socioemotional dysfunction and the greater good: a case study.Neurocase · 2024Article
- A framework for quantifying the coupling between brain connectivity and heartbeat dynamics: Insights into the disrupted network physiology in Parkinson's disease.Human brain mapping · 2024Article
- A synergetic turn in cognitive neuroscience of brain diseases.Trends in cognitive sciences · 2024Review
- Altered empathy processing in frontotemporal dementia A task-based fMRI study.bioRxiv : the preprint server for biology · 2024Article
- The Coding Logic of Interoception.Annual review of physiology · 2024Review
- Personalization of Affective Models Using Classical Machine Learning: A Feasibility Study.Applied sciences (Basel, Switzerland) · 2024Article
- The BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds.Scientific data · 2023Article
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Authors and funding
12 authors.
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Abstract
Disease-specific mechanisms underlying emotion recognition difficulties in behavioural-variant frontotemporal dementia (bvFTD), Alzheimer's disease (AD), and Parkinson's disease (PD) are unknown. Interoceptive accuracy, accurately detecting internal cues (e.g., one's heart beating), and cognitive abilities are candidate mechanisms underlying emotion recognition. One hundred and sixty-eight participants (52 bvFTD; 41 AD; 24 PD; 51 controls) were recruited. Emotion recognition was measured via the Facial Affect Selection Task or the Mini-Social and Emotional Assessment Emotion Recognition Task. Interoception was assessed with a heartbeat detection task. Participants pressed a button each time they: 1) felt their heartbeat (Interoception); or 2) heard a recorded heartbeat (Exteroception-control). Cognition was measured via the Addenbrooke's Cognitive Examination-III or the Montreal Cognitive Assessment. Voxel-based morphometry analyses identified neural correlates associated with emotion recognition and interoceptive accuracy. All patient groups showed worse emotion recognition and cognition than controls (all P's ≤ .008). Only the bvFTD showed worse interoceptive accuracy than controls (P < .001). Regression analyses revealed that in bvFTD worse interoceptive accuracy predicted worse emotion recognition (P = .008). Whereas worse cognition predicted worse emotion recognition overall (P < .001). Neuroimaging analyses revealed that the insula, orbitofrontal cortex, and amygdala were involved in emotion recognition and interoceptive accuracy in bvFTD. Here, we provide evidence for disease-specific mechanisms for emotion recognition difficulties. In bvFTD, emotion recognition impairment is driven by inaccurate perception of the internal milieu. Whereas, in AD and PD, cognitive impairment likely underlies emotion recognition deficits. The current study furthers our theoretical understanding of emotion and highlights the need for targeted interventions.
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