ArticleScience advances2023
Local brain oscillations and interregional connectivity differentially serve sensory and expectation effects on pain.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Article
- Distributed cortical learning through LEC-mediated γ-synchrony.Nature communications · 2026Article
- Dynamic Global and Local Enhancement of Theta-Band Functional Networks as Neural Markers of Spinal Cord Stimulation Efficacy in Disorders of Consciousness.CNS neuroscience & therapeutics · 2026Article
- Neural encoding of pain is robust within but unstable between individuals.PLoS biology · 2026Article
- Predicting Pain: Electroencephalography Signatures of Neural Integration During Experimental Tonic Thermal Pain.European journal of pain (London, England) · 2026Article
- Temporal predictions shape somatosensory perception.Nature communications · 2026Article
- Dynamic expectation strength and precision shape human pain perception through shared and dissociable α-oscillatory mechanisms.PLoS biology · 2026Article
- Altered cortical alpha modulations and connectivity in complex regional pain syndrome.The journal of pain · 2026Article
- Transcranial Alternating Current Stimulation for Pain: Mixed Evidence and the Path to Precision Neuromodulation.Brain sciences · 2026Review
- Article
- Graph-theoretical analysis of EEG-based functional connectivity during emotional experience in virtual reality for emotion recognition.Scientific reports · 2025Article
- Exploring electroencephalographic chronic pain biomarkers: a mega-analysis.EBioMedicine · 2025Article
- A comprehensive EEG dataset of laser-evoked potentials for pain research.Scientific data · 2025Article
- EEG oscillations reveal neuroplastic changes in pain processing associated with long-term meditation.Scientific reports · 2025Article
- A computational mechanism of cue-stimulus integration for pain in the brain.Science advances · 2024Article
- EEG Techniques with Brain Activity Localization, Specifically LORETA, and Its Applicability in Monitoring Schizophrenia.Journal of clinical medicine · 2024Review
- Cue-based modulation of pain stimulus expectation: do ongoing oscillations reflect changes in pain perception? A registered report.Royal Society open science · 2024Article
- Neuroimaging-based evidence for sympathetic correlation between brain activity and peripheral vasomotion during pain anticipation.Scientific reports · 2024Article
- Changes in alpha, theta, and gamma oscillations in distinct cortical areas are associated with altered acute pain responses in chronic low back pain patients.Frontiers in neuroscience · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pain emerges from the integration of sensory information about threats and contextual information such as an individual's expectations. However, how sensory and contextual effects on pain are served by the brain is not fully understood so far. To address this question, we applied brief painful stimuli to 40 healthy human participants and independently varied stimulus intensity and expectations. Concurrently, we recorded electroencephalography. We assessed local oscillatory brain activity and interregional functional connectivity in a network of six brain regions playing key roles in the processing of pain. We found that sensory information predominantly influenced local brain oscillations. In contrast, expectations exclusively influenced interregional connectivity. Specifically, expectations altered connectivity at alpha (8 to 12 hertz) frequencies from prefrontal to somatosensory cortex. Moreover, discrepancies between sensory information and expectations, i.e., prediction errors, influenced connectivity at gamma (60 to 100 hertz) frequencies. These findings reveal how fundamentally different brain mechanisms serve sensory and contextual effects on pain.
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