Evidence map›Paper›PMID 37074920›Full record

ArticleACS chemical biology2023

New High-Throughput Screen Discovers Novel Ligands of Full-Length Nuclear Receptor LRH-1.

M Merced Malabanan, Pratima Chapagain, Zeinab Haratipour, Woong Jae Choi, Abigail R Orun, Raymond D Blind

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Fragment-Based Discovery of Drug-like LRH-1 Agonists.ACS medicinal chemistry letters · 2025
    Article
  5. Fatty Acid Mimetic Fragments as Liver Receptor Homologue-1 Modulators.ACS pharmacology & translational science · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

M Merced MalabananDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Pratima ChapagainDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Zeinab HaratipourDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Woong Jae ChoiDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Abigail R OrunDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.ORCID 0000-0003-3090-1363
Raymond D BlindDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.ORCID 0000-0002-1358-6309
Vanderbilt University Medical Center · USVanderbilt University · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3M
MULTIDISCIPLINARY TRAINING IN MOLECULAR ENDOCRINOLOGYT32DK007563 · NIDDK · VANDERBILT UNIVERSITY · PI Richard M O'Brien · 1988 to 2026
$15.9M
Translational Research in Endocrinology And Diabetes (TREAD)T32DK007061 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Sarah S Jaser, KEVIN D NISWENDER · 1986 to 2026
$8.0M
VGM: Vanderbilt Genomic Medicine Training ProgramT32HG008341 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Nancy J Cox, Joseph F. Peterson · 2016 to 2026
$2.8M
Full-length LRH-1 structural regulationR01GM138873 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLIND, RAYMOND DANIEL · 2020 to 2023
$1.4M
A new kinase inhibitor for glioblastomaR21CA243036 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLIND, RAYMOND DANIEL · 2019 to 2020
$407k
NCI NIH HHS P30 CA068485NCI NIH HHS R21 CA243036NHGRI NIH HHS T32 HG008341NIDDK NIH HHS P30 DK020593NIDDK NIH HHS T32 DK007061NIDDK NIH HHS T32 DK007563NIGMS NIH HHS R01 GM138873
6 · The paper itself

Abstract

Nuclear receptor liver receptor homolog-1 (LRH-1,

Indexed as

Gene Expression RegulationReceptors, Cytoplasmic and NuclearHumansIvermectinLigandsTranscription FactorsabamectinIvermectinLigandsNR5A2 protein, humanReceptors, Cytoplasmic and NuclearTranscription Factors

Identifiers

PMID37074920
PMCPMC10404069
OpenAlexW4366352190

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.