ArticleCell reports2023
Multi-synaptic boutons are a feature of CA1 hippocampal connections in the stratum oriens.
Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- GRASPing experience-dependent protein expression signatures enriched for hippocampal engram cell synapses.Science advances · 2026Article
- Aging-independent decrease of complex multi-spine boutons in hippocampal area CA1 after contextual fear conditioning.Molecular brain · 2025Article
- A workflow for semi-automated volume correlative light microscopy and transmission electron tomography.Journal of microscopy · 2025Article
- Synaptic architecture of a memory engram in the mouse hippocampus.Science (New York, N.Y.) · 2025Article
- Absolute Number of Three Populations of Interneurons and All GABAergic Synapses in the Human Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Early and late place cells during postnatal development of the hippocampus.Nature communications · 2024Article
- Lifelong absence of microglia alters hippocampal glutamatergic networks but not synapse and spine density.EMBO reports · 2024Article
- Hippocampal glial inflammatory markers are differentially altered in a novel mouse model of perimenopausal cerebral amyloid angiopathy.Frontiers in aging neuroscience · 2023Article
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Authors and funding
16 authors at 5 institutions in 2 countries.
Funding
Abstract
Excitatory synapses are typically described as single synaptic boutons (SSBs), where one presynaptic bouton contacts a single postsynaptic spine. Using serial section block-face scanning electron microscopy, we found that this textbook definition of the synapse does not fully apply to the CA1 region of the hippocampus. Roughly half of all excitatory synapses in the stratum oriens involved multi-synaptic boutons (MSBs), where a single presynaptic bouton containing multiple active zones contacted many postsynaptic spines (from 2 to 7) on the basal dendrites of different cells. The fraction of MSBs increased during development (from postnatal day 22 [P22] to P100) and decreased with distance from the soma. Curiously, synaptic properties such as active zone (AZ) or postsynaptic density (PSD) size exhibited less within-MSB variation when compared with neighboring SSBs, features that were confirmed by super-resolution light microscopy. Computer simulations suggest that these properties favor synchronous activity in CA1 networks.
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