Evidence map›Paper›PMID 37074818›Full record

ArticleAging2023

Exogenous exposures shape genetic predisposition to lipids, Alzheimer's, and coronary heart disease in the MLXIPL gene locus.

Yury Loika, Elena Loiko, Fan Feng, Eric Stallard, Anatoliy I Yashin, Konstantin Arbeev, Allison L Kuipers, Mary F Feitosa, Michael A Province, Alexander M Kulminski

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yury LoikaBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA.
Elena LoikoBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA.
Fan FengBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA.
Eric StallardBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA.
Anatoliy I YashinBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA.
Konstantin ArbeevBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA.
Allison L KuipersDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA.
Michael A ProvinceDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA.
Alexander M KulminskiBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA.
Social Science Research Council · USDuke University · USUniversity of Pittsburgh · US

Funding

The Long Life Family StudyU19AG063893 · NIA · WASHINGTON UNIVERSITY · PI Stacy Andersen, KAARE CHRISTENSEN · 2019 to 2026
$125.4M
Long Life Family Study: Data Management and Coordinating CenterU01AG023746 · NIA · WASHINGTON UNIVERSITY · PI PROVINCE, MICHAEL A. · 2004 to 2018
$29.2M
The Long Life Family StudyU01AG023755 · NIA · BOSTON MEDICAL CENTER · PI PERLS, THOMAS T · 2004 to 2018
$13.2M
Plasma beta-amyloid in long lived families: genetics and risk of ADU01AG023749 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI COSENTINO, STEPHANIE ANN, LEE, JOSEPH HYUNGWOO · 2004 to 2018
$13.0M
Multicenter Study on Exceptional Survival in Families: The Long Life Family StudyU01AG023744 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B., ZMUDA, JOSEPH M. · 2004 to 2018
$12.0M
Long Life Family Study: Duke Univ./Univ. of Southern Denmark Field CenterU01AG023712 · NIA · DUKE UNIVERSITY · PI CHRISTENSEN, KAARE · 2004 to 2018
$10.4M
Relationships among Genetic Regulators of Aging Health and LifespanP01AG043352 · NIA · DUKE UNIVERSITY · PI YASHIN, ANATOLIY I · 2014 to 2018
$8.7M
ApoE2 and protective molecular signatures in Alzheimer's disease and agingR01AG061853 · NIA · DUKE UNIVERSITY · PI KULMINSKI, ALEXANDER M · 2018 to 2022
$3.9M
Personalized genetic profiles of risk and resilience in Alzheimer's and vascular diseasesR01AG065477 · NIA · DUKE UNIVERSITY · PI KULMINSKI, ALEXANDER M · 2020 to 2024
$3.8M
Dissecting genetic and non-genetic heterogeneity in predisposition to Alzheimer's disease and vascular traits in pleiotropic contextR01AG070488 · NIA · DUKE UNIVERSITY · PI KULMINSKI, ALEXANDER M, OUKRAINTSEVA, SVETLANA V. · 2020 to 2024
$2.8M
Molecular signatures of health and life span disparities between whites and African-Americans in the APOE regionR01AG047310 · NIA · DUKE UNIVERSITY · PI KULMINSKI, ALEXANDER M · 2015 to 2019
$2.5M
NIA NIH HHS P01 AG043352NIA NIH HHS R01 AG047310NIA NIH HHS R01 AG061853NIA NIH HHS R01 AG065477NIA NIH HHS R01 AG070488NIA NIH HHS U01 AG023712NIA NIH HHS U01 AG023744NIA NIH HHS U01 AG023746NIA NIH HHS U01 AG023749NIA NIH HHS U01 AG023755NIA NIH HHS U19 AG063893
6 · The paper itself

Abstract

Associations of single nucleotide polymorphisms (SNPs) of the

Indexed as

Alzheimer DiseaseCoronary DiseaseCholesterol, HDLGenetic Predisposition to DiseaseHumansRisk FactorsTriglyceridesCholesterol, HDLTriglyceridesAlzheimer's diseasecoronary heart diseaselipidsMLXIPLtriglycerides

Identifiers

PMID37074818
PMCPMC10449285
OpenAlexW4366263058

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.