Evidence map›Paper›PMID 37074807›Full record

Trial reportClinical and translational science2022

Pharmacokinetics of oral mannitol for bowel preparation for colonoscopy.

Giancarla Fiori, Cristiano Spada, Pietro Soru, Gian Eugenio Tontini, Ivana Bravi, Bruno Mario Cesana, Paola Cesaro, Gianpiero Manes, Anna Orsatti, Alberto Prada and 7 more

Open access · goldAbstract readRandomized Controlled TrialMulticenter Study
In one paragraph

Trial report in Clinical and translational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Bowel Preparation for Colonoscopy: The Patient Point of View.Digestive diseases (Basel, Switzerland) · 2025
    Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Evaluating bowel preparation tolerability in IBD: a phase 3Frontiers in gastroenterology (Lausanne, Switzerland) · 2025
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 3 countries.

Giancarla FioriDivisione di Endoscopia, Istituto Europeo di Oncologia, IRCCS, Milan, Italy.ORCID 0000-0002-6388-3184
Cristiano SpadaU.O. Endoscopia Digestiva, Fondazione Poliambulanza - Istituto Ospedaliero, Brescia, Italy.
Pietro SoruDivisione di Endoscopia, Istituto Europeo di Oncologia, IRCCS, Milan, Italy.
Gian Eugenio TontiniDepartment of Pathophysiology and Organ Transplantation, University of Milan, Milan, Italy.
Ivana BraviDivisione di Endoscopia, Istituto Europeo di Oncologia, IRCCS, Milan, Italy.
Bruno Mario CesanaDepartment of Molecular and Transactional Medicine, Statistics and Biomathematics Unit, Faculty of Medicine and Surgery, University of Brescia, Brescia, Italy.
Paola CesaroU.O. Endoscopia Digestiva, Fondazione Poliambulanza - Istituto Ospedaliero, Brescia, Italy.
Gianpiero ManesU.O.C. Gastroenterologia, ASST Rhodense, Presidi di Rho e Garbagnate, Garbagnate Milanese (MI), Italy.
Anna OrsattiMedical Affairs, NTC, Milan, Italy.ORCID 0000-0002-7325-5237
Alberto PradaServizio Gastroenterologia ed Endoscopia Digestiva, Istituto Auxologico Italiano, Milan, Italy.
Alessandro QuadarellaU.O. Endoscopia Digestiva, Fondazione Poliambulanza - Istituto Ospedaliero, Brescia, Italy.
Mario SchettinoU.O.C. Gastroenterologia, ASST Rhodense, Presidi di Rho e Garbagnate, Garbagnate Milanese (MI), Italy.
Luisa SpinaGastroenterology and Endoscopy Unit, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Cristina TrovatoDivisione di Endoscopia, Istituto Europeo di Oncologia, IRCCS, Milan, Italy.
Marino CarnovaliOspedale Papa Giovanni XXIII, Bergamo, Italy.
Maurizio VecchiDepartment of Pathophysiology and Organ Transplantation, University of Milan, Milan, Italy.
Satisfaction Study Group
European Institute of Oncology · ITFondazione Poliambulanza Istituto Ospedaliero · ITATS Sardegna (Italy) · ITUniversity of Milan · ITAssociated Press · USBrescia University · USFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITGlobal Affairs Canada · CAIRCCS Istituto Auxologico Italiano · ITOspedale Papa Giovanni XXIII · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to define the pharmacokinetics (PKs) of oral mannitol used as an osmotic laxative for bowel preparation for colonoscopy. The PKs of oral mannitol was evaluated in a substudy as part of a phase II dose-finding, international, multicenter, randomized, parallel-group, endoscopist-blinded study. Patients were randomly assigned to take 50, 100, or 150 g mannitol. Venous blood samples were drawn at baseline (T

Indexed as

ColonoscopyAdministration, OralArea Under CurveBiological AvailabilityCross-Over StudiesHumans

Identifiers

PMID37074807
PMCPMC9579383
OpenAlexW4290731461

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.