Evidence map›Paper›PMID 37074558›Full record

ArticleEndocrine2023

Enlargement of a metastatic lymph node from differentiated thyroid cancer after COVID-19 vaccination.

Laura Valerio, Alessandro Prete, Ferruccio Santini, Laura Agate, Rossella Elisei, Francesco Latrofa

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Endocrine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Laura Valerio *Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy.ORCID 0000-0001-7723-7020
Alessandro Prete *Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy.
Ferruccio SantiniDepartment of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy.
Laura AgateDepartment of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy.
Rossella EliseiDepartment of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy. rossella.elisei@med.unipi.it.ORCID 0000-0002-5333-9257
Francesco LatrofaDepartment of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy.
University of Pisa · IT

Funding

Università di Pisa 539901
6 · The paper itself

Abstract

backgroundThe massive vaccination campaign against COVID-19 has granted a high level of protection against the severe forms of the disease at the price of some mild adverse events.

objectiveTo underline that COVID-19 vaccination can induce a transient enlargement of lymph-node metastases in differentiated thyroid cancer patients. CASE PRESENTATION: We describe the clinical, laboratory, and imaging features of a 60-year-old woman affected by paratracheal lymph-node relapse of Hurtle Cell Carcinoma who came to our attention after full COVID-19 vaccination because of neck swelling and pain. In April 2021, after 5 years of stable structural disease, the patient presented an enlargement of the metastatic lymph node, associated with a rise of serum thyroglobulin (from 4.6 to 14.7 pg/mL). Anti-inflammatory treatment was started and pain and swelling remitted after 15 days. At the subsequent evaluation, at neck ultrasound, the right paratracheal lesion was smaller and thyroglobulin dropped to 3.9 pg/mL.

conclusionsWe report the case of an enlargement of metastatic lymph node from differentiated thyroid cancer after COVID-19 vaccination. We warn clinicians to identify features of inflammatory response due to COVID-19 vaccination in order to prevent unwarranted surgical treatment.

Indexed as

AdenocarcinomaCarcinoma, PapillaryCOVID-19Thyroid NeoplasmsCOVID-19 VaccinesFemaleHumansLymph NodesMiddle AgedNeoplasm Recurrence, LocalThyroglobulinThyroidectomyCOVID-19 VaccinesThyroglobulinCOVID-19 vaccinationInflammatory responseLymphadenopathyLymph-node metastasesThyroid cancer

Identifiers

PMID37074558
PMCPMC10113119
OpenAlexW4366352858

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.