Evidence map›Paper›PMID 37074539›Full record

Observational studyNeurosurgical review2023

Glucose-albumin ratio as new biomarker for predicting mortality after intracerebral hemorrhage.

Jialing He, Yu Zhang, Tiangui Li, Haidong Deng, Peng Wang, Weelic Chong, Yang Hai, Lvlin Chen, Chao You, Lu Jia and 2 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Neurosurgical review, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Jialing HeDepartment of Neurosurgery, The Second Affiliated Hospital of Guangzhou Medical University, No. 250, Changgang East Road, Guangzhou, 510260, Guangdong, China.
Yu ZhangDepartment of Neurosurgery, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Tiangui LiDepartment of Neurosurgery, Longquan Hospital, Chengdu, Sichuan, China.
Haidong DengDepartment of Neurosurgery, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Peng WangDepartment of Neurosurgery, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Weelic ChongDepartment of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA.
Yang HaiSidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Lvlin ChenDepartment of Critical Care Medicine, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Chao YouDepartment of Neurosurgery, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, 610041, Sichuan, China.
Lu JiaDepartment of Neurosurgery, Shanxi Provincial People's Hospital, Taiyuan, Shanxi, China.
Yezhong WangDepartment of Neurosurgery, The Second Affiliated Hospital of Guangzhou Medical University, No. 250, Changgang East Road, Guangzhou, 510260, Guangdong, China. wangyezhong@gzhmu.edu.cn.
Fang FangDepartment of Neurosurgery, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, 610041, Sichuan, China. fangfang01@scu.edu.cn.
Chengdu University · CNSichuan University · CNThomas Jefferson University · USGuangzhou Medical University · CNSecond Affiliated Hospital of Guangzhou Medical University · CNShanxi Medical University · CNWest China Hospital of Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aims to evaluate the prognostic value of blood-based biomarkers and their combinations, in particular the glucose-albumin ratio (GAR), in patients with spontaneous intracerebral hemorrhage (ICH).

methodsA retrospective observational study on 2481 patients from one hospital was conducted and validated with 602 patients from another. We assessed 15 biomarkers and focused on GAR to elucidate its prognostic and predictive value for outcomes in both cohorts. The primary outcome was mortality at 90 days.

resultsThe ratio of glucose-to-albumin, defined as GAR, was superior to other biomarkers for predicting mortality at 90 days in patients with ICH (AUC = 0.72). High GAR (using the best cutoff value of 0.19) was associated with increased mortality at 90 days (odds ratios of 1.90, 95% CI 1.54-2.34) and all-cause mortality in the first 3 years after admission (hazard ratio of 1.62, 95% CI 1.42-1.86). All aforementioned findings for GAR were successfully validated in an external independent cohort.

conclusionsGAR may be a valuable biomarker for predicting the mortality of patients with ICH.

Indexed as

Cerebral HemorrhageGlucoseAlbuminsBiomarkersHumansPrognosisRetrospective StudiesAlbuminsBiomarkersGlucoseGlucose-albumin ratioIntracerebral hemorrhageMortalityPrognosis

Identifiers

PMID37074539
OpenAlexW4366351780

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.