Evidence map›Paper›PMID 37074472›Full record

ArticleCurrent microbiology2023

Cuscuta reflexa Possess Potent Inhibitory Activity Against Human Malaria Parasite: An In Vitro and In Vivo Study.

Sashi Bhusan Ojha, Raj Kumar Sah, Evanka Madan, Ruby Bansal, Shaktirekha Roy, Shailja Singh, Gunanidhi Dhangadamajhi

Abstract read
PubMed Publisher
In one paragraph

Article in Current microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sashi Bhusan OjhaDepartment of Biotechnology, Maharaja Sriram Chandra Bhanja Deo University, Baripada, Odisha, 757003, India.
Raj Kumar SahSpecial Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, 110067, India.
Evanka MadanSpecial Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, 110067, India.
Ruby BansalSpecial Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, 110067, India.
Shaktirekha RoyDepartment of Biotechnology, Maharaja Sriram Chandra Bhanja Deo University, Baripada, Odisha, 757003, India.
Shailja SinghSpecial Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, 110067, India. shailja.jnu@gmail.com.ORCID http://orcid.org/0000-0001-5286-6605
Gunanidhi DhangadamajhiDepartment of Biotechnology, Maharaja Sriram Chandra Bhanja Deo University, Baripada, Odisha, 757003, India. gunarmrc@gmail.com.ORCID http://orcid.org/0000-0002-7934-0862

Funding

Department Of Science and Technology, Govt. Of India IF-150683Department Of Science and Technology, Govt. Of Odisha 27552800232014/20Drug and Pharmaceuticals Research Programe P/569/2016-1/TDTDrug and Pharmaceuticals Research Programe SS
6 · The paper itself

Abstract

Drug resistance to practically all antimalarial drugs in use necessitate the development of new chemotherapeutics against malaria. In this aspect, traditionally used plants with folklore reputation are the pillar for drug discovery. Cuscuta reflexa being traditionally used in the treatment of malaria in Odisha, India we aimed to experimentally validate its antimalarial potential. Different solvent extracts of C. reflexa or column fractions from a promising solvent extract were evaluated for in vitro anti-plasmodial activity against Plasmodium falciparum strain Pf3D7. Potent fractions were further evaluated for inhibition of parasite growth against different drug resistant strains. Safety of these fractions was determined by in vitro cyto-toxicity, and therapeutic effectiveness was evaluated by suppression of parasitemia and improvement in survival of experimental mice. Besides, their immunomodulatory effect was investigated in Pf-antigen stimulated RAW cells. GCMS fingerprints of active fractions was determined. Column separation of methanol extract which showed the highest in vitro antiplasmodial activity (IC

Indexed as

AntimalarialsCuscutaMalariaParasitesAnimalsHumansMicePlant ExtractsPlasmodium bergheiSolventsAntimalarialsPlant ExtractsSolvents

Identifiers

PMID37074472

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.