Evidence map›Paper›PMID 37074199›Full record

ArticleJournal of bacteriology2023

A Novel Pathway for Biosynthesis of the Herbicidal Phosphonate Natural Product Phosphonothrixin Is Widespread in Actinobacteria.

Luke Bown, Ryuichi Hirota, Michelle N Goettge, Jerry Cui, David T Krist, Lingyang Zhu, Constantin Giurgiu, Wilfred A van der Donk, Kou-San Ju, William W Metcalf

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Microbial genomics · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Luke BownInstitute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Ryuichi HirotaGraduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima City, Hiroshima, Japan.
Michelle N GoettgeInstitute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Jerry CuiDepartment of Microbiology, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-8165-7340
David T KristInstitute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Lingyang ZhuDepartment of Chemistry and the Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Constantin GiurgiuInstitute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Wilfred A van der DonkInstitute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.ORCID 0000-0002-5467-7071
Kou-San JuDepartment of Microbiology, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0003-0438-6740
William W MetcalfInstitute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.ORCID 0000-0002-0182-0671
University of Illinois Urbana-Champaign · USHoward Hughes Medical Institute · USThe Ohio State University · USHiroshima University · JP

Funding

Structural Elucidation and Biosynthesis P01GM077596 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI METCALF, WILLIAM W · 2007 to 2016
$15.3M
Discovery, biosynthesis and bioactivity of phosphonic acid natural productsR01GM127659 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI METCALF, WILLIAM W · 2018 to 2024
$2.2M
Genomics-Accelerated Discovery and Biosynthesis of Phosphonic Acid Natural ProductsR01GM137135 · NIGMS · OHIO STATE UNIVERSITY · PI JU, KOU-SAN · 2020 to 2024
$1.7M
NIGMS NIH HHS P01 GM077596NIGMS NIH HHS R01 GM127659NIGMS NIH HHS R01 GM137135
6 · The paper itself

Abstract

Phosphonothrixin is an herbicidal phosphonate natural product with an unusual, branched carbon skeleton. Bioinformatic analyses of the

Indexed as

ActinobacteriaBiological ProductsHerbicidesOrganophosphonatesBacteriaMultigene FamilyPhenylpyruvic Acids3,4-dihydroxyphenylpyruvic acidBiological ProductsHerbicidesOrganophosphonatesPhenylpyruvic Acidsphosphonothrixinbiosynthesisenzymeherbicidenatural productphosphonate

Identifiers

PMID37074199
PMCPMC10210982
OpenAlexW4366352203

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.