ArticleEnvironmental health perspectives2023
Prenatal Exposure to Air Pollution and Pre-Labor Rupture of Membranes in a Prospective Cohort Study: The Role of Maternal Hemoglobin and Iron Supplementation.
Article in Environmental health perspectives, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Association of household air pollution exposure and anemia among pregnant women: Analysis of baseline data from 'Household Air Pollution Intervention Network (HAPIN)' trial.Environment international · 2024Trial
- Prediction of premature rupture of fetal membranes using deep learning in East China.Scientific reports · 2026Article
- Depressive symptoms mediate the associations between air pollution exposure and anemia risk: a nationwide longitudinal study in China.BMC public health · 2026Article
- Association between residential greenness and anemia risk among women of reproductive age in low- and middle-income countries.Frontiers in public health · 2026Article
- Impact of short-term air pollution exposure on premature rupture of membranes in the North China Plain, 2015-2021: a multicity case-crossover study.Journal of global health · 2025Article
- Environmental Contaminants, Iron Deficiency, and Iron-Deficiency Anemia: A Review of the Literature.Scientifica · 2025Review
- Maternal Exposure to Environmental Air Pollution and Premature Rupture of Membranes: Evidence from Southern China.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Ambient air pollution and the dynamic transitions of stroke and dementia: a population-based cohort study.EClinicalMedicine · 2024Article
- Maternal exposure to ambient air pollution mixture and premature rupture of membranes: Evidence from a large cohort in Southern California (2008-2018).Environment international · 2023Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExposure to air pollution in prenatal period is associated with prelabor rupture of membranes (PROM). However, the sensitive exposure time windows and the possible biological mechanisms underlying this association remain unclear.
objectiveWe aimed to identify the sensitive time windows of exposure to air pollution for PROM risk. Further, we examined whether maternal hemoglobin levels mediate the association between exposure to air pollution and PROM, as well as investigated the potential effect of iron supplementation on this association.
methodFrom 2015 to 2021, 6,824 mother-newborn pairs were enrolled in the study from three hospitals in Hefei, China. We obtained air pollutant data [particulate matter (PM) with aerodynamic diameter
resultsWe found significant association between prenatal exposure to air pollution and increased PROM risk after adjusting for confounders, and the critical exposure windows of
conclusionsPrenatal exposure to air pollution, especially in the 21st to 24th weeks of pregnancy, is associated with PROM risk, which is partly mediated by maternal hemoglobin levels. Iron supplementation in anemia pregnancies may have protective effects against PROM risk associated with exposure to low-medium air pollution. https://doi.org/10.1289/EHP11134.
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