Evidence map›Paper›PMID 37074148›Full record

ArticleeLife2023

Are some mutations more equal than others?

Auden Cote-L'Heureux, Yogesh N K Maithania, Melissa Franco, Konstantin Khrapko

Abstract readComment
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Auden Cote-L'HeureuxDepartment of Biology, Northeastern University, Boston, United States.
Yogesh N K MaithaniaDepartment of Biology, Northeastern University, Boston, United States.
Melissa FrancoDepartment of Biology, Northeastern University, Boston, United States.
Konstantin KhrapkoDepartment of Biology, Northeastern University, Boston, United States.ORCID 0000-0002-9250-8033

Funding

mtDNA phylogeny of the germ line: mechanism, structure and function of the mtDNA bottleneckR01HD091439 · NICHD · NORTHEASTERN UNIVERSITY · PI KHRAPKO, KONSTANTIN, TILLY, JONATHAN LEE · 2018 to 2022
$1.6M
NICHD NIH HHS R01 HD091439
6 · The paper itself

Abstract

A large-scale study of mutations in mitochondrial DNA has revealed a subset that do not accumulate with age.

Indexed as

DNA, MitochondrialMitochondriaMutationDNA, Mitochondrialagingduplex sequencinggeneticsgenomicsmitochondrial DNAmousesomatic mutations

Identifiers

PMID37074148
PMCPMC10115439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.