ArticleeLife2023
Dynamic fibronectin assembly and remodeling by leader neural crest cells prevents jamming in collective cell migration.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
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- Multiscale Modeling of Embryonic Morphogenesis from Fertilization to Organogenesis.NPJ systems biology and applications · 2026Review
- Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis.Current biology : CB · 2026Article
- A phase field model with stochastic input simulates cellular gradient sensing, morphodynamics, and fidelity of haptotaxis.bioRxiv : the preprint server for biology · 2026Article
- Identification of neural crest and melanoma cancer cell invasion and migration genes using high-throughput screening and deep attention networks.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- The influence of cell phenotype on collective cell invasion into the extracellular matrix.Bulletin of mathematical biology · 2025Article
- Formins and Arp2/3 Reciprocally Regulate Contact Guidance on Aligned Collagen Fibrils.Cellular and molecular bioengineering · 2025Article
- A Simple Framework for Agent-Based Modeling with Extracellular Matrix.Bulletin of mathematical biology · 2025Article
- Confined cell migration along extracellular matrix space in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Extracellular matrix dynamics: A key regulator of cell migration across length-scales and systems.Current opinion in cell biology · 2024Review
- Modeling the extracellular matrix in cell migration and morphogenesis: a guide for the curious biologist.Frontiers in cell and developmental biology · 2024Review
- Article
- Lens placode modulates extracellular matrix formation during early eye development.Differentiation; research in biological diversityArticle
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
Collective cell migration plays an essential role in vertebrate development, yet the extent to which dynamically changing microenvironments influence this phenomenon remains unclear. Observations of the distribution of the extracellular matrix (ECM) component fibronectin during the migration of loosely connected neural crest cells (NCCs) lead us to hypothesize that NCC remodeling of an initially punctate ECM creates a scaffold for trailing cells, enabling them to form robust and coherent stream patterns. We evaluate this idea in a theoretical setting by developing an individual-based computational model that incorporates reciprocal interactions between NCCs and their ECM. ECM remodeling, haptotaxis, contact guidance, and cell-cell repulsion are sufficient for cells to establish streams in silico, however, additional mechanisms, such as chemotaxis, are required to consistently guide cells along the correct target corridor. Further model investigations imply that contact guidance and differential cell-cell repulsion between leader and follower cells are key contributors to robust collective cell migration by preventing stream breakage. Global sensitivity analysis and simulated gain- and loss-of-function experiments suggest that long-distance migration without jamming is most likely to occur when leading cells specialize in creating ECM fibers, and trailing cells specialize in responding to environmental cues by upregulating mechanisms such as contact guidance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.