ArticleEMBO reports2023
Clostridium perfringens virulence factors are nonredundant activators of the NLRP3 inflammasome.
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Article in EMBO reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
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Who cites it
23 citing papers in PubMed, 21 citations in OpenAlex.
- Synergetic attenuated inflammatory response and increased apoptosis confer high pathogenicity ofVirulence · 2026Article
- The NLRP3 inflammasome at the crossroads of innate immune signaling and cell death.Cellular & molecular immunology · 2026Review
- Exploitation of cholesterol-dependent cytolysins for targeted biosensing and therapeutic systems.Drug delivery and translational research · 2026Review
- The challenge of cell death switching in inflammasome-targeted therapies for bacterial and viral infections.Communications biology · 2026Review
- From Glycocalyx Shedding to Microvascular Collapse in Sepsis: Endothelial Pathophysiology, Organ Dysfunction, and Mechanistic Biomarkers.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Review
- Sensing the spectrum: diverse stimuli for the NLRP3 inflammasome.Communications biology · 2026Review
- Microbiome biomarkers in autism spectrum disorder: Toward prediction, diagnosis, and prognosis.Cell reports. Medicine · 2026Review
- Aminoglycoside Resistance Among Clinical Bacterial Isolates in Sétif, Algeria: Epidemiology, Multidrug Resistance, and Virulence Features.Antibiotics (Basel, Switzerland) · 2026Article
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- Glucose-Lowering Effects and Safety ofMicroorganisms · 2025Article
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- Molecular mechanisms and regulation of inflammasome activation and signaling: sensing of pathogens and damage molecular patterns.Cellular & molecular immunology · 2025Review
- Type A cholesterol-dependent cytolysins translocate to the trans-Golgi network for NLRP3 inflammasome activation.Nature immunology · 2025Article
- Bacterial infection in weaned piglets promotes diarrhea by inducing the NLRP3 inflammasome-pyroptosis pathway.Science China. Life sciences · 2025Article
- Updated insights into the molecular networks for NLRP3 inflammasome activation.Cellular & molecular immunology · 2025Review
- A Critical Review of Postbiotics as Promising Novel Therapeutic Agents for Clostridial Infections.Probiotics and antimicrobial proteins · 2025Review
- NLRP3 and beyond: inflammasomes as central cellular hub and emerging therapeutic target in inflammation and disease.Frontiers in immunology · 2025Review
- From Inflammasomes to Pyroptosis: Molecular Mechanisms in Chronic Intestinal Diseases - Opportunity or Challenge?Journal of inflammation research · 2025Review
- Sprayable inflammasome-inhibiting lipid nanorods in a polymeric scaffold for psoriasis therapy.Nature communications · 2024Article
- The Barrier Disruption and Pyroptosis of Intestinal Epithelial Cells Caused by Perfringolysin O (PFO) fromCells · 2024Article
Corrections and comments
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Authors and funding
23 authors at 4 institutions in 2 countries.
Anukriti Mathur *Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.ORCID 0000-0002-7004-301X
Callum Kay *Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.ORCID 0000-0002-0985-6206
Yansong XueDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Abhimanu PandeyDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.ORCID 0000-0002-2367-3422
Jiwon LeeCentre for Advanced Microscopy, The Australian National University, Canberra, ACT, Australia.ORCID 0000-0003-2382-2106
Weidong JingDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.ORCID 0000-0002-6747-6076
Daniel Enosi TuipulotuDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.ORCID 0000-0002-6442-4633
Jordan Lo PilatoDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.ORCID 0000-0003-4042-0934
Shouya FengDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Chinh NgoDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Anyang ZhaoDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.ORCID 0000-0001-8907-1048
Cheng ShenDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.ORCID 0000-0002-6098-1205
Melanie RugCentre for Advanced Microscopy, The Australian National University, Canberra, ACT, Australia.ORCID 0000-0002-4687-9677
Lisa A MiosgeDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Ines I AtmosukartoLipotek Pty Ltd. The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Jason D PriceLipotek Pty Ltd. The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Sidra A AliDivision of Genome Science and Cancer, The Australian National University, Canberra, ACT, Australia.
Elizabeth E GardinerDivision of Genome Science and Cancer, The Australian National University, Canberra, ACT, Australia.ORCID 0000-0001-9453-9688
Avril Ab RobertsonSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.ORCID 0000-0002-9652-8357
Milena M AwadInfection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, VIC, Australia.ORCID 0000-0002-9275-3979
Dena LyrasInfection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, VIC, Australia.ORCID 0000-0003-2345-9271
Nadeem O KaakoushSchool of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia.ORCID 0000-0003-4017-1077
Si Ming ManDivision of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.ORCID 0000-0002-5079-2857
Australian National University · AUDiscovery Institute · USThe University of Queensland · AUUNSW Sydney · AU
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammasome signaling is a central pillar of innate immunity triggering inflammation and cell death in response to microbes and danger signals. Here, we show that two virulence factors from the human bacterial pathogen Clostridium perfringens are nonredundant activators of the NLRP3 inflammasome in mice and humans. C. perfringens lecithinase (also known as phospolipase C) and C. perfringens perfringolysin O induce distinct mechanisms of activation. Lecithinase enters LAMP1
Indexed as
InflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinAnimalsCell Adhesion Molecules, NeuronalClostridium perfringensHumansInflammationInterleukin-1betaMiceNerve Growth FactorsVirulence FactorsCell Adhesion Molecules, NeuronalInflammasomesInterleukin-1betaNerve Growth FactorsNINJ1 protein, humanNinj1 protein, mouseNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseVirulence Factorscell deathinflammasomeinnate immunitytoxins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.