Evidence map›Paper›PMID 37073733›Full record

ReviewHypertension (Dallas, Tex. : 1979)2023

Noise and Air Pollution as Risk Factors for Hypertension: Part II-Pathophysiologic Insight.

Omar Hahad, Sanjay Rajagopalan, Jos Lelieveld, Mette Sørensen, Marin Kuntic, Andreas Daiber, Mathias Basner, Mark Nieuwenhuijsen, Robert D Brook, Thomas Münzel

Open access · bronzeAbstract readReview
In one paragraph

Review in Hypertension (Dallas, Tex. : 1979), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
30.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.

  1. Pooled it
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  12. Current hypertension epidemiology and contemporary approaches using the "Real-World Evidence Cycle" framework.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
  13. Review
  14. Article
  15. 2024 Thai guidelines on the treatment of hypertension.Asian biomedicine : research, reviews and news · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 6 countries.

Omar HahadDepartment of Cardiology-Cardiology I, University Medical Center of the Johannes Gutenberg University Mainz, Germany (O.H., M.K., A.D., T.M.).ORCID 0000-0001-7823-7671
Sanjay RajagopalanHarrington Heart and Vascular Institute, University Hospitals and Case Western Reserve University, Cleveland, OH (S.R.).ORCID 0000-0001-6669-8163
Jos LelieveldAtmospheric Chemistry Department, Max Planck Institute for Chemistry, Mainz, Germany (J.L.).ORCID 0000-0001-6307-3846
Mette SørensenEnvironment and Cancer, Danish Cancer Society Research Center, Copenhagen, Denmark (M.S.).
Marin KunticDepartment of Cardiology-Cardiology I, University Medical Center of the Johannes Gutenberg University Mainz, Germany (O.H., M.K., A.D., T.M.).ORCID 0000-0003-2435-851X
Andreas DaiberDepartment of Cardiology-Cardiology I, University Medical Center of the Johannes Gutenberg University Mainz, Germany (O.H., M.K., A.D., T.M.).ORCID 0000-0002-2769-0094
Mathias BasnerDepartment of Psychiatry, Unit for Experimental Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (M.B.).
Mark NieuwenhuijsenInstitute for Global Health (ISGlobal), Barcelona, Spain (M.N.).
Robert D BrookDivision of Cardiovascular Diseases, Department of Internal Medicine, Wayne State University, Detroit, MI (R.D.B.).ORCID 0000-0002-8521-7262
Thomas MünzelDepartment of Cardiology-Cardiology I, University Medical Center of the Johannes Gutenberg University Mainz, Germany (O.H., M.K., A.D., T.M.).ORCID 0000-0001-5503-4150
Johannes Gutenberg University Mainz · DEMax Planck Institute for Chemistry · DERoskilde University · DKUniversitat Pompeu Fabra · ESUniversity Hospitals of Cleveland · USUniversity of Pennsylvania · USWayne State University · US

Funding

Diversity Suppplement (CIRCADIAN) Circadian Disruption as Mediator of Cardiometabolic Risk in Air PollutionR35ES031702 · NIEHS · CASE WESTERN RESERVE UNIVERSITY · PI Sanjay Rajagopalan · 2021 to 2026
$5.9M
Diet-Environment Interactions in InflammationR01ES017290 · NIEHS · UNIVERSITY OF MARYLAND BALTIMORE · PI RAJAGOPALAN, SANJAY · 2010 to 2014
$1.8M
NIEHS NIH HHS R01 ES017290NIEHS NIH HHS R35 ES031702
6 · The paper itself

Abstract

Traffic noise and air pollution are environmental stressors found to increase risk for cardiovascular events. The burden of disease attributable to environmental stressors and cardiovascular disease globally is substantial, with a need to better understand the contribution of specific risk factors that may underlie these effects. Epidemiological observations and experimental evidence from animal models and human controlled exposure studies suggest an essential role for common mediating pathways. These include sympathovagal imbalance, endothelial dysfunction, vascular inflammation, increased circulating cytokines, activation of central stress responses, including hypothalamic and limbic pathways, and circadian disruption. Evidence also suggests that cessation of air pollution or noise through directed interventions alleviates increases in blood pressure and intermediate surrogate pathways, supporting a causal link. In the second part of this review, we discuss the current understanding of mechanisms underlying and current gaps in knowledge and opportunities for new research.

Indexed as

Air PollutantsAir PollutionCardiovascular DiseasesHypertensionAnimalsEnvironmental ExposureHumansParticulate MatterRisk FactorsAir PollutantsParticulate Matterair pollutioncardiovascular diseasescytokinesinflammationnoiseoxidative stress

Identifiers

PMID37073733
PMCPMC10330112
OpenAlexW4366350918

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.