Evidence map›Paper›PMID 37073715›Full record

ArticleInternational journal of immunopathology and pharmacology

Identification of an immune-related genes signature to predict risk of recurrence for patients with laryngeal squamous cell carcinoma.

Xiu Hong, Yang Li, Qian Lv, Jun An, Ying Liu, Xiuli Wang, Rui Li, Yuqiang Hu, Bing Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xiu HongDepartment of Central Laboratory, Xuzhou Central Hospital, Xuzhou, China.
Yang LiDepartment of Central Laboratory, Xuzhou Central Hospital, Xuzhou, China.
Qian LvDepartment of Central Laboratory, Xuzhou Central Hospital, Xuzhou, China.
Jun AnDepartment of Otolaryngology-Head and Neck Surgery, Xuzhou Central Hospital, China.
Ying LiuDepartment of Central Laboratory, Xuzhou Central Hospital, Xuzhou, China.
Xiuli WangDepartment of Central Laboratory, Xuzhou Central Hospital, Xuzhou, China.
Rui LiDepartment of Central Laboratory, Xuzhou Central Hospital, Xuzhou, China.
Yuqiang HuXuzhou Clinical School of Nanjing Medical University, Xuzhou, China.
Bing LiuDepartment of Otolaryngology-Head and Neck Surgery, Xuzhou Central Hospital, China.ORCID 0000-0002-7376-4234
Xuzhou Central Hospital · CNXuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveNumerous studies indicate that immune-related genes (IRGs) are closely related to tumorigenesis and tumor progression. We aimed to establish a robust IRGs-based signature to predict risk of recurrence for patients with laryngeal squamous cell carcinoma (LSCC).

methodsGene expression profiles were acquired to select differentially expressed IRGs (DEIRGs) between tumor and adjacent normal tissues. Functional enrichment analysis was performed to explore the biological roles of DEIRGs in LSCC. Univariate Cox analyses and LASSO regression model were used to construct a IRGs-based signature with the ability to predict recurrence for LSCC patients.

resultsA total of 272 DEIRGs were identified, of which 20 DEIRGs were significantly associated with recurrence-free survival (RFS). Subsequently, we constructed an eleven-IRGs signature that could classify patients into high-risk or low-risk groups in TCGA-LSCC training cohort. Patients in high-risk groups suffered from shorter RFS (log-rank

conclusionOur findings for the first time constructed a robust IRGs-based signature to precisely predict risk of recurrence and further provided a deeper understanding of IRGs regulatory mechanism in LSCC pathogenesis.

Indexed as

CarcinogenesisHead and Neck NeoplasmsHumansPrognosisResearch DesignRisk FactorsSquamous Cell Carcinoma of Head and Neckimmune-related genesLaryngeal squamous cell carcinomarecurrence-free survivalsignature

Identifiers

PMID37073715
PMCPMC10127216
OpenAlexW4366352206

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.