Evidence map›Paper›PMID 37073586›Full record

ArticleDevelopmental psychobiology2023

Neurophysiology of predictable unpleasant event processing in pre-adolescents and early adolescents, part II: Reflex and event-related potential markers of defensive reactivity and peripheral attention modulation.

Christopher T Sege, Lisa M McTeague, Molly Kegley, Curtisha Shacklewood, Colleen A Halliday, Casey D Calhoun, Jane E Joseph, Zachary W Adams, Greg Hajcak, Carla Kmett Danielson

Open access · bronzeAbstract read
In one paragraph

Article in Developmental psychobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Christopher T SegeDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID 0000-0003-0040-0939
Lisa M McTeagueDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
Molly KegleyDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
Curtisha ShacklewoodDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
Colleen A HallidayDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
Casey D CalhounDepartment of Psychiatry, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.
Jane E JosephDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
Zachary W AdamsDepartment of Psychiatry, Indiana University, Indianapolis, Indiana, USA.
Greg HajcakDepartment of Psychology, Florida State University, Tallahassee, Florida, USA.
Carla Kmett DanielsonDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
Medical University of South Carolina · USFlorida State University · USIndiana University – Purdue University Indianapolis · USUniversity of North Carolina at Chapel Hill · US

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
Traumatic Stress Across the Lifespan: A Biopsychosocial Training ProgramT32MH018869 · NIMH · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI CARLA KMETT DANIELSON, DEAN Gaines KILPATRICK · 1988 to 2026
$7.2M
Threat-Related Negative Valence Systems, Child Victimization, and Anxiety_SupplementR01MH112209 · NIMH · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DANIELSON, CARLA KMETT · 2017 to 2022
$4.1M
Modeling and Modulating Mechanisms of Escape, Avoidance, and Approach in the Anxiety Disorder SpectrumK23MH123931 · NIMH · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SEGE, CHRISTOPHER · 2021 to 2025
$1.0M
NCATS NIH HHS UL1 TR001450NIMH NIH HHS K23 MH123931NIMH NIH HHS R01 MH112209NIMH NIH HHS T32 MH018869
6 · The paper itself

Abstract

The ability to anticipate and process predictable unpleasant events, while also regulating emotional reactivity, is an adaptive skill. The current article and a companion in this issue test for potential changes in predictable event processing across the childhood-to-adolescence transition, a key developmental period for biological systems that support cognitive/ emotional abilities. While the companion article focuses on neurophysiology of predictable event processing itself, the present article examines peripheral emotional response regulation and attention modulation that coincides with event processing. A total of 315 third-, sixth-, or ninth-grade individuals saw 5-s cues predicting "scary," "every day," or uncertain pictures, and here, blink reflexes and brain event-related potentials (ERPs) elicited by peripheral noise probes are analyzed. During the cue, blink reflexes and probe ERP (P200) amplitudes were increased when the cue predicted scary, compared to everyday, content. After picture onset, reflex enhancement by scary content then disappeared for predictable images, whereas ERP modulation was similar regardless of predictability. Patterns are similar to those in adults and suggest (1) sustained defensive response priming and enhancement of peripheral attention during aversive anticipation, and (2) an ability, even in pre-adolescents, to downregulate defensive priming while maintaining attentional modulation once an awaited predictable aversive event occurs.

Indexed as

Evoked PotentialsReflex, StartleAdolescentAdultAttentionChildElectroencephalographyEmotionsHumansPhotic Stimulationadolescentattentionelectrophysiologyemotionstress

Identifiers

PMID37073586
PMCPMC10948024
OpenAlexW4362608279

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.