ArticleCartilage2023
Total Knee Arthroplasty (TKA): When Do the Risks of TKA Overcome the Benefits? Double Risk of Failure in Patients up to 65 Years Old.
Article in Cartilage, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Quantitative Assessment of BB-02 Therapy Effect on Cartilage Status in Patients Affected by Early Knee Osteoarthritis
The Effect of a Novel Joint Distraction Knee Orthosis for Treating Medial Knee Osteoarthritis
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Matrix-assisted autologous chondrocyte transplantation is effective at mid/long-term for knee lesions: A systematic review and meta-analysis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Pooled it
- Effect of ultrasound-guided genicular nerve neurolysis versus sham procedure on pain in patients with knee osteoarthritis: a randomized clinical trial.Pain medicine (Malden, Mass.) · 2026Trial
- Leukocytes Do Not Influence the Safety and Efficacy of Platelet-Rich Plasma Injections for the Treatment of Knee Osteoarthritis: A Double-Blind Randomized Controlled Trial.The American journal of sports medicine · 2024Trial
- Cell-based therapy injections for the management of knee osteoarthritis: The ESSKA-ICRS consensus. Recommendations using the RAND/UCLA appropriateness method for different clinical scenarios.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- Younger age doubles medium-term revision risk after total knee arthroplasty: A nationwide multicenter cohort of 5980 knees from the French SCORE I registry.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- High Tibial Osteotomy for Knee Osteoarthritis with Genu Varum: A Retrospective, Observational Study.Journal of functional morphology and kinesiology · 2026Article
- Safety and Survival Rate of a Biomimetic Osteochondral Scaffold for the Treatment of Lesions of the Knee Articular Surface.Orthopaedic journal of sports medicine · 2026Article
- Immuno-based profiling of knee osteoarthritis patients identifies baseline characteristics associated with positive response to autologous platelet-rich plasma injection at one-year follow-up.Frontiers in immunology · 2026Article
- Subchondral bone repair potential of an osteochondral scaffold augmented with BMP-2 or strontium-enriched amorphous calcium phosphate: a co-cultureFrontiers in medicine · 2026Article
- Rethinking the role of cartilage loss: the influence of intra- and extra-articular factors on symptoms in advanced knee osteoarthritis.Bone & joint open · 2025Article
- Cemented mobile-bearing medial unicompartmental knee arthroplasty provides long-term implant survival and sustained functional performance in young and active patients aged 60 or below.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- Depressive symptoms influence progression to total knee arthroplasty in patients with early knee osteoarthritis: Evidence from the Osteoarthritis Initiative database.Journal of experimental orthopaedics · 2025Article
- Effect of corticosteroids and hyaluronic acid injections on knee osteoarthritis trajectory.Journal of experimental orthopaedics · 2025Article
- Perioperative and Follow-Up Analyses of Primary Posterior Stabilized and Cruciate Retaining Knee Arthroplasty.Journal of clinical medicine · 2025Article
- Article
- Unicompartmental osteoarthritis: High survival rate with a combined mechanical and biological salvage approach as alternative to metal resurfacing: Results at minimum 10 years of follow-up.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- Comparison of Clinical Efficacy and Mechanical Characteristics of Two Knee Distraction Devices With Relevance for Clinical Practice.Cartilage · 2024Article
- Evaluating the Quality and Reliability of Total Knee Arthroplasty Rehabilitation Exercises on the Social Media Platform TikTok.Arthroplasty today · 2024Article
- Ultrasounds outperform magnetic resonance imaging in quantifying meniscal extrusion in patients with knee osteoarthritis.Journal of experimental orthopaedics · 2024Article
- Biomechanical analysis of patient specific cone vs conventional stem in revision total knee arthroplasty.Journal of orthopaedic surgery and research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to document the survival rate in the middle-aged patient group up to 65 years old and to compare it with other age groups of patients undergoing total knee arthroplasty (TKA) for knee osteoarthritis (OA).
designThe Register of Orthopaedic Prosthetic Implants (RIPO) regional registry was used to analyze the results of patients <80 years old affected by primary OA and treated with TKA from 2000 to 2019. The database was investigated according to the age group: younger than 50 years, 50-65 years, or 66-79 years, with the aim to estimate revision surgeries and implant survivorship.
resultsA total of 45,488 TKAs for primary OA were included in the analysis (M: 11,388; F: 27,846). The percentage of patients <65 years old increased from 13.5% to 24.8% between 2000 and 2019 (
conclusionsTKA use in the middle-aged patient population up to 65 years old increased significantly over time. These patients present a double risk of failure with respect to older patients. This is particularly important considering the increasing life expectancy and the emergence of new joint preserving strategies, which could postpone the need for TKA to an older age.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.