ArticleNature reviews. Methods primers2022
In vivo hypermutation and continuous evolution.
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Article in Nature reviews. Methods primers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
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0cells of the map it votes in
89citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
89 citing papers in PubMed.
- Hijacking host RNA polymerase for processive in situ mutagenesis.Synthetic and systems biotechnology · 2027Article
- Article
- Phage-assisted continuous evolution of enzymes for noncanonical tyrosine biosynthesis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Harnessing the central dogma: Enzyme-driven gene diversification strategies for in cellulo continuous directed evolution.Fundamental research · 2026Review
- Sequence-free landscape inference for directed evolution.PLoS computational biology · 2026Article
- Exploring the Evolutionary Landscape with Targeted In Vivo Hypermutations.Biomedicines · 2026Review
- Ancestral Protein Reconstruction Uncovers a Thermotolerant Rieske Oxygenase with EnhancedACS synthetic biology · 2026Article
- Anti-CRISPR-mediated continuous directed evolution of CRISPR-Cas9 in human cells.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Phage-assisted continuous evolution of enzymes for noncanonical tyrosine biosynthesis.bioRxiv : the preprint server for biology · 2026Article
- Rapid directed evolution guided by protein language models and epistatic interactions.Science (New York, N.Y.) · 2026Article
- Harnessing Nature's Algorithm: From Test Tubes to Autonomous In Vivo Evolution.Biotechnology journal · 2026Review
- Continuous evolution of a halogenase enzyme with improved solubility and activity for sustainable bioproduction.Nature communications · 2026Article
- Continuous Directed Evolution of a Short-Lived Plant Histidinol Dehydrogenase.ACS synthetic biology · 2026Article
- Toward a systems metabolic engineering approach to improve thermotolerance of Escherichia coli.Microbial cell factories · 2026Review
- Engineering Fluoroacetate Dehalogenase by Growth-Based Selections on Non-Natural Organofluorides.Angewandte Chemie (International ed. in English) · 2026Article
- MicroDFBEST: A dCas12b-derived dual-function base editor with programmable editing characteristics for microbial genetic engineering.Synthetic and systems biotechnology · 2026Article
- Continuous Hypermutation and Evolution of Luciferase Variants.ACS chemical biology · 2026Article
- Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026Review
- Tuning evolvability via plasmid copy number and regulatory architecture.Nature communications · 2025Article
- Anti-CRISPR-mediated continuous directed evolution of CRISPR-Cas9 in human cells.bioRxiv : the preprint server for biology · 2025Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Rosana S MolinaDepartment of Biomedical Engineering, University of California, Irvine, CA 92617, USA.
Gordon RixDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA.
Amanuella A MengisteDepartment of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
Beatriz AlvarezDepartment of Microbial Biotechnology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CNB-CSIC), Darwin 3, Campus UAM Cantoblanco, 28049 Madrid, Spain.
Daeje SeoDepartment of Chemistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, South Korea.
Haiqi ChenBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Juan HurtadoDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.
Qiong ZhangDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.
Jorge Donato García-GarcíaTecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Av. General Ramon Corona 2514, Nuevo Mexico, C.P. 45138, Zapopan, Jalisco, Mexico.
Zachary J HeinsBiological Design Center, Boston University, Boston, Massachusetts, USA.
Patrick J AlmhjellDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Frances H ArnoldDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Ahmad S KhalilBiological Design Center, Boston University, Boston, Massachusetts, USA.
Andrew D HansonHorticultural Sciences Department, University of Florida, Gainesville, FL 32611, USA.
John E DueberDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.
David V SchafferDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.
Fei ChenBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Seokhee KimDepartment of Chemistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, South Korea.
Luis Ángel FernándezDepartment of Microbial Biotechnology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CNB-CSIC), Darwin 3, Campus UAM Cantoblanco, 28049 Madrid, Spain.
Matthew D ShouldersDepartment of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
Chang C LiuDepartment of Biomedical Engineering, University of California, Irvine, CA 92617, USA.
Funding
ePACE: automation platforms for adaptable and scalable continuous evolution of biomolecules with therapeutic potentialR01EB027793 · NIBIB · BROAD INSTITUTE, INC. · PI Ahmad Samir Khalil, DAVID R LIU · 2019 to 2026
$6.1MSynthetic genetic systems for rapid biomolecular evolution in vivoR35GM136297 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIU, CHANG C · 2020 to 2024
$2.4MLeveraging Next-Generation Directed Evolution Platforms and Chemical Control of Proteostasis to Deliver Robust Biotechnologies and Illuminate Roles of Chaperone Networks in Protein EvolutionR35GM136354 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SHOULDERS, MATTHEW DONALD · 2020 to 2024
$2.1MDevelopment of a Biocatalytic Platform for Convergent Synthesis of Chiral AminesR01GM125887 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ARNOLD, FRANCES H · 2018 to 2021
$1.2MNIBIB NIH HHS R01 EB027793NIGMS NIH HHS R01 GM125887NIGMS NIH HHS R35 GM136297NIGMS NIH HHS R35 GM136354
Abstract
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Indexed as
Cheater mutationsClonal interferenceConsensus sequencingDirected evolutionGreedy mutationsHypermutationIntegration cassetteProcessivitySign epistasisUnique molecular identifier
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.