ReviewMolecular and cellular pediatrics2023
Perinatal origins of bronchopulmonary dysplasia-deciphering normal and impaired lung development cell by cell.
Review in Molecular and cellular pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 18 citations in OpenAlex.
- Targeting the SIRT1-TLR4 axis attenuates oxidative inflammation in a cellular model of bronchopulmonary dysplasia.Pediatric research · 2026Article
- A nomogram to predict bronchopulmonary dysplasia in very preterm and/or very low birth weight infants with early-onset sepsis.BMC pediatrics · 2026Observational
- Development and internal validation of a clinical nomogram for predicting bronchopulmonary dysplasia in preterm infants.Experimental and therapeutic medicine · 2026Article
- The Inflammatory Nexus of Bronchopulmonary Dysplasia: From Molecular Pathways to Precision Therapeutics.Mediators of inflammation · 2026Review
- Pulmonary neuroendocrine cells in pediatric asthma and bronchopulmonary dysplasia: neuroimmune-developmental mechanisms and translational implications.Frontiers in medicine · 2026Review
- Association between placental histological chorioamnionitis and respiratory distress syndrome in preterm infants: a retrospective cohort study.Frontiers in pediatrics · 2026Article
- Mitochondrial quality control mechanisms as molecular targets for impaired lung development: from fetuses to neonates.Respiratory research · 2025Review
- Prenatal lipopolysaccharide exposure programs the early-life lung development by modulating mesenchymal fibroblasts in a time- and dose-dependent manner.BMC medicine · 2025Article
- p53 maintains lineage fidelity during lung capillary injury-repair in neonatal hyperoxia.JCI insight · 2025Article
- Towards early detection and disease interception of COPD across the lifespan.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Impact of placental pathology on the risk of bronchopulmonary dysplasia in preterm infants: The role of gestational age and sex.European journal of pediatrics · 2025Observational
- Role of systemic inflammation response index and prognostic nutritional index in the prediction of moderate-to-severe bronchopulmonary dysplasia in very preterm infants.Translational pediatrics · 2025Article
- Maternal inflammatory biomarkers and neonatal characteristics as predictors of bronchopulmonary dysplasia in preterm infants: a retrospective cohort study.Frontiers in medicine · 2025Article
- When prenatal infection meets postnatal hyperoxia: Better models for bronchopulmonary dysplasia and its therapeutic approaches.Chinese medical journal pulmonary and critical care medicine · 2024Review
- Extracellular Vesicle ASC: A Novel Mediator for Lung-Brain Axis in Preterm Brain Injury.American journal of respiratory cell and molecular biology · 2024Article
- Endothelial deletion ofbioRxiv : the preprint server for biology · 2024Article
- Mesenchymal stromal/stem cells and bronchopulmonary dysplasia.Frontiers in cell and developmental biology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bronchopulmonary dysplasia (BPD) is a multifactorial disease occurring as a consequence of premature birth, as well as antenatal and postnatal injury to the developing lung. BPD morbidity and severity depend on a complex interplay between prenatal and postnatal inflammation, mechanical ventilation, and oxygen therapy as well as associated prematurity-related complications. These initial hits result in ill-explored aberrant immune and reparative response, activation of pro-fibrotic and anti-angiogenic factors, which further perpetuate the injury. Histologically, the disease presents primarily by impaired lung development and an arrest in lung microvascular maturation. Consequently, BPD leads to respiratory complications beyond the neonatal period and may result in premature aging of the lung. While the numerous prenatal and postnatal stimuli contributing to BPD pathogenesis are relatively well known, the specific cell populations driving the injury, as well as underlying mechanisms are still not well understood. Recently, an effort to gain a more detailed insight into the cellular composition of the developing lung and its progenitor populations has unfold. Here, we provide an overview of the current knowledge regarding perinatal origin of BPD and discuss underlying mechanisms, as well as novel approaches to study the perturbed lung development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.