ArticleScientific reports2023
Resting-state functional connectivity disruption between the left and right pallidum as a biomarker for subthreshold depression.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Aberrant functional connectivity of the globus pallidus in the modulation of the relationship between childhood trauma and major depressive disorder.Journal of psychiatry & neuroscience : JPNTrial
- Frequency-dependent alterations of degree centrality in patients with poststroke depression: a resting-state functional MRI study.Neuroreport · 2026Article
- The role of the subcortical structures in subthreshold depression: evidence from static and dynamic functional connectivity.Brain structure & function · 2026Article
- Altered Salience-Default Mode Network Dynamics in Subclinical Depression: A Preclustering-Based Co-Activation Pattern Analysis.CNS neuroscience & therapeutics · 2026Article
- A Systematic Review: Investigating Biomarkers of Anhedonia and Amotivation in Depression and Cannabis Use.JAACAP open · 2025Review
- Effects of depression and anxiety symptoms on cognitive inhibition: A cross-sectional study of structural and functional MRI evidence.Medicine · 2025Observational
- Individualized identification value of stress-related network structural-functional properties and HPA axis reactivity for subthreshold depression.Translational psychiatry · 2024Article
- Exploring habenular structural connectivity in Parkinson's disease: insights from 7 T MRI study.Journal of neurology · 2024Article
- Resting-state functional magnetic resonance imaging and support vector machines for the diagnosis of major depressive disorder in adolescents.World journal of psychiatry · 2024Review
- Topological differences of striato-thalamo-cortical circuit in functional brain network between premature ejaculation patients with and without depression.Brain and behavior · 2024Article
- Identifying and verifying Huntington's disease subtypes: Clinical features, neuroimaging, and cytokine changes.Brain and behavior · 2024Article
- Lower functional connectivity state transitions during affective processing correlate with subsequent impairment in sustaining positive affect in subthreshold depression.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the identification of late adolescents with subthreshold depression (StD) may provide a basis for developing effective interventions that could lead to a reduction in the prevalence of StD and prevent the development of major depressive disorder, knowledge about the neural basis of StD remains limited. The purpose of this study was to develop a generalizable classifier for StD and to shed light on the underlying neural mechanisms of StD in late adolescents. Resting-state functional magnetic resonance imaging data of 91 individuals (30 StD subjects, 61 healthy controls) were included to build an StD classifier, and eight functional connections were selected by using the combination of two machine learning algorithms. We applied this biomarker to an independent cohort (n = 43) and confirmed that it showed generalization performance (area under the curve = 0.84/0.75 for the training/test datasets). Moreover, the most important functional connection was between the left and right pallidum, which may be related to clinically important dysfunctions in subjects with StD such as anhedonia and hyposensitivity to rewards. Investigation of whether modulation of the identified functional connections can be an effective treatment for StD may be an important topic of future research.
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