Evidence map›Paper›PMID 37072402›Full record

ArticleNature communications2023

Hybrid photoacoustic and fast super-resolution ultrasound imaging.

Shensheng Zhao, Jonathan Hartanto, Ritin Joseph, Cheng-Hsun Wu, Yang Zhao, Yun-Sheng Chen

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shensheng ZhaoDepartment of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Jonathan HartantoDepartment of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-0507-9200
Ritin JosephDepartment of Materials Science and Engineering, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Cheng-Hsun WuVerily Life Sciences, South San Francisco, CA, USA.
Yang ZhaoDepartment of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-0154-3483
Yun-Sheng ChenDepartment of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL, USA. yunsheng@illinois.edu.ORCID 0000-0001-8823-970X
University of Illinois Urbana-Champaign · US

Funding

SINGLE MOLECULAR NANOSCOPIC IMAGING ON LIVING CELLSR21GM139022 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ZHAO, YANG · 2020 to 2021
$436k
NIGMS NIH HHS R21 GM139022NIGMS NIH HHS R21GM139022
6 · The paper itself

Abstract

The combination of photoacoustic (PA) imaging and ultrasound localization microscopy (ULM) with microbubbles has great potential in various fields such as oncology, neuroscience, nephrology, and immunology. Here we developed an interleaved PA/fast ULM imaging technique that enables super-resolution vascular and physiological imaging in less than 2 seconds per frame in vivo. By using sparsity-constrained (SC) optimization, we accelerated the frame rate of ULM up to 37 times with synthetic data and 28 times with in vivo data. This allows for the development of a 3D dual imaging sequence with a commonly used linear array imaging system, without the need for complicated motion correction. Using the dual imaging scheme, we demonstrated two in vivo scenarios challenging to image with either technique alone: the visualization of a dye-labeled mouse lymph node showing nearby microvasculature, and a mouse kidney microangiography with tissue oxygenation. This technique offers a powerful tool for mapping tissue physiological conditions and tracking the contrast agent biodistribution non-invasively.

Indexed as

Contrast MediaImaging, Three-DimensionalAnimalsMiceMicrobubblesMicroscopyTissue DistributionUltrasonographyContrast Media

Identifiers

PMID37072402
PMCPMC10113238
OpenAlexW4366280094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.