Evidence map›Paper›PMID 37072338›Full record

ArticleStroke and vascular neurology2023

Somatic

Ran Huo, Yingxi Yang, Hongyuan Xu, Shaozhi Zhao, Dong Song, Jiancong Weng, Ruochen Ma, Yingfan Sun, Jie Wang, Yuming Jiao and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke and vascular neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Ran Huo *Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yingxi Yang *Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Hong Kong, China.
Hongyuan Xu *Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Shaozhi ZhaoDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Dong SongDivision of Life Science, Center for Systems Biology and Human Health and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China.
Jiancong WengDepartment of Neurosurgery, China-Japan Friendship Hospital, Beijing, China.
Ruochen MaDivision of Life Science, Center for Systems Biology and Human Health and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China.
Yingfan SunDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jie WangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yuming JiaoDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0001-8351-4602
Junze ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Qiheng HeDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0001-6715-298X
Ruolei WuSchool of Medical Technology, Beijing Institute of Technology, Beijing, China.
Shuo WangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Ji-Zong ZhaoDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Junting ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jiguang WangDepartment of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Hong Kong, China caoyong@bjtth.org jgwang@ust.hk.
Yong CaoDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China caoyong@bjtth.org jgwang@ust.hk.ORCID 0000-0002-8289-1120
Capital Medical University · CNHong Kong University of Science and Technology · HKBeijing Institute of Technology · CNChina-Japan Friendship Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveExtra-axial cavernous hemangiomas (ECHs) are sporadic and rare intracranial occupational lesions that usually occur within the cavernous sinus. The aetiology of ECHs remains unknown.

methodsWhole-exome sequencing was performed on ECH lesions from 12 patients (discovery cohort) and droplet digital polymerase-chain-reaction (ddPCR) was used to confirm the identified mutation in 46 additional cases (validation cohort). Laser capture microdissection (LCM) was carried out to capture and characterise subgroups of tissue cells. Mechanistic and functional investigations were carried out in human umbilical vein endothelial cells and a newly established mouse model.

resultsWe detected somatic

conclusionsWe identified a somatic

Indexed as

Hemangioma, CavernousHemangioma, Cavernous, Central Nervous SystemAnimalsEndothelial CellsHumansMiceMutationSignal TransductionVascular Malformations

Identifiers

PMID37072338
PMCPMC10800255
OpenAlexW4366333071

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.