Evidence map›Paper›PMID 37072130›Full record

ArticleEuropean heart journal2023

Psychological therapies for depression and cardiovascular risk: evidence from national healthcare records in England.

Céline El Baou, Roopal Desai, Claudia Cooper, Natalie L Marchant, Steve Pilling, Marcus Richards, Rob Saunders, Joshua E J Buckman, Elisa Aguirre, Amber John and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.

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  16. Heart-brain axis: Pushing the boundaries of cardiovascular molecular imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Céline El BaouAdapt Lab, Research Department of Clinical, Educational and Health Psychology, UCL, 1-19 Torrington Place, Camden, London WC1E 7HB, UK.ORCID 0000-0002-7212-1835
Roopal DesaiAdapt Lab, Research Department of Clinical, Educational and Health Psychology, UCL, 1-19 Torrington Place, Camden, London WC1E 7HB, UK.ORCID 0000-0003-4221-1546
Claudia CooperCentre for Psychiatry and Mental Health, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.ORCID 0000-0002-2777-7616
Natalie L MarchantMarchant Lab, Division of Psychiatry, UCL, London, UK.ORCID 0000-0003-0669-6910
Steve PillingCentre for Outcomes Research and Effectiveness, Research Department of Clinical, Educational and Health Psychology, UCL, London, UK.
Marcus RichardsMRC Unit for Lifelong Health and Ageing at UCL, UCL, London, UK.ORCID 0000-0001-9191-2192
Rob SaundersAdapt Lab, Research Department of Clinical, Educational and Health Psychology, UCL, 1-19 Torrington Place, Camden, London WC1E 7HB, UK.ORCID 0000-0002-7077-8729
Joshua E J BuckmanCentre for Outcomes Research and Effectiveness, Research Department of Clinical, Educational and Health Psychology, UCL, London, UK.ORCID 0000-0002-2281-0907
Elisa AguirreNorth East London NHS Foundation Trust (NELFT), London, UK.ORCID 0000-0003-4096-5109
Amber JohnAdapt Lab, Research Department of Clinical, Educational and Health Psychology, UCL, 1-19 Torrington Place, Camden, London WC1E 7HB, UK.ORCID 0000-0002-8207-7698
Joshua StottAdapt Lab, Research Department of Clinical, Educational and Health Psychology, UCL, 1-19 Torrington Place, Camden, London WC1E 7HB, UK.ORCID 0000-0003-1361-053X
University College London · GBSt Pancras Hospital · GBMRC Unit for Lifelong Health and Ageing · GBNorth East London NHS Foundation Trust · GBQueen Mary University of London · GB

Funding

Medical Research Council MC_UU_00019/1Medical Research Council MC_UU_00019/3Medical Research Council MC_UU_12019/3Wellcome Trust 201292/Z/16/Z
6 · The paper itself

Abstract

aimsPeople with depression are up to 72% more at risk to develop cardiovascular disease (CVD) in their lifetime. Evidence-based psychotherapies are first-line interventions for the treatment of depression and are delivered nationally in England through the National Health Service via the Improving Access to Psychological Therapy (IAPT) primary care programme. It is currently unknown whether positive therapy outcomes may be associated with cardiovascular risk reduction. This study aimed to examine the association between psychotherapy outcomes for depression and incident CVD. METHODS AND

resultsA cohort of 636 955 individuals who have completed a course of psychotherapy was built from linked electronic healthcare record databases of national coverage in England: the national IAPT database, the Hospital Episode Statistics (HES) database, and the HES-ONS (Office of National Statistics) mortality database. Multivariable Cox models adjusting for clinical and demographic covariates were run to estimate the association between reliable improvement from depression and the risk of subsequent incidence of cardiovascular events. After a median follow-up of 3.1 years, reliable improvement from depression symptoms was associated with a lower risk of new onset of any CVD [hazard ratio (HR): 0.88, 95% confidence interval (CI): 0.86, 0.89], coronary heart disease (HR: 0.89, 95% CI: 0.86, 0.92), stroke (HR: 0.88, 95% CI: 0.83, 0.94), and all-cause mortality (HR: 0.81, 95% CI: 0.78, 0.84). This association was stronger in the under 60 compared with the over 60 for all outcomes. Results were confirmed in sensitivity analyses.

conclusionManagement of depression through psychological interventions may be associated with reduced risk of CVD. More research is needed to understand the causality of these associations.

Indexed as

Cardiovascular DiseasesDelivery of Health CareDepressionHeart Disease Risk FactorsHumansRisk FactorsState MedicineCardiovascular diseaseCoronary heart diseaseDepressionElectronic healthcare recordsEvidence-base psychological therapiesPrimary healthcareStroke

Identifiers

PMID37072130
PMCPMC10163979
OpenAlexW4366339706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.