Evidence map›Paper›PMID 37071931›Full record

ReviewAnnual review of virology2023

Impact of the Microbiota on Viral Infections.

Danielle E Campbell, Yuhao Li, Harshad Ingle, Megan T Baldridge

Open access · hybridAbstract readReview
In one paragraph

Review in Annual review of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Gingipain proteases from the bacteriumProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Viruses · 2025
    Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Fecal Transplantation in Hematopoietic Transplantation.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Danielle E CampbellDepartment of Medicine, Division of Infectious Diseases and Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA; email: mbaldridge@wustl.edu.
Yuhao LiDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Harshad IngleDepartment of Medicine, Division of Infectious Diseases and Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA; email: mbaldridge@wustl.edu.
Megan T BaldridgeDepartment of Medicine, Division of Infectious Diseases and Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA; email: mbaldridge@wustl.edu.
Washington University in St. Louis · US

Funding

Pediatric Gastroenterology Research Training ProgramT32DK077653 · NIDDK · WASHINGTON UNIVERSITY · PI PHILLIP I TARR · 2007 to 2026
$5.8M
Role of CD300 Family in Norovirus Tropism, Persistence, and ImmunityR01AI127552 · NIAID · WASHINGTON UNIVERSITY · PI BALDRIDGE, MEGAN T, FREMONT, DAVED H. · 2017 to 2021
$3.5M
Norovirus regulation via bacterial modulation of interferon-lambdaR01AI139314 · NIAID · WASHINGTON UNIVERSITY · PI BALDRIDGE, MEGAN T · 2019 to 2023
$2.0M
NIAID NIH HHS R01 AI127552NIAID NIH HHS R01 AI139314NIDDK NIH HHS T32 DK077653
6 · The paper itself

Abstract

The mammalian gastrointestinal tract (GIT) hosts a diverse and highly active microbiota composed of bacteria, eukaryotes, archaea, and viruses. Studies of the GIT microbiota date back more than a century, although modern techniques, including mouse models, sequencing technology, and novel therapeutics in humans, have been foundational to our understanding of the roles of commensal microbes in health and disease. Here, we review the impacts of the GIT microbiota on viral infection, both within the GIT and systemically. GIT-associated microbes and their metabolites alter the course of viral infection through a variety of mechanisms, including direct interactions with virions, alteration of the GIT landscape, and extensive regulation of innate and adaptive immunity. Mechanistic understanding of the full breadth of interactions between the GIT microbiota and the host is still lacking in many ways but will be vital for the development of novel therapeutics for viral and nonviral diseases alike.

Indexed as

Gastrointestinal MicrobiomeMicrobiotaVirus DiseasesVirusesAnimalsGastrointestinal TractHumansMammalsMiceinterferonmetabolitesmicrobiomemicrobiotasignalingvirome

Identifiers

PMID37071931
PMCPMC10543481
OpenAlexW4366248384

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.