Evidence map›Paper›PMID 37070996›Full record

ArticleRadiology2023

Phase-resolved Functional Lung (PREFUL) MRI-derived Ventilation and Perfusion Parameters Predict Future Lung Transplant Loss.

Jens Vogel-Claussen, Till F Kaireit, Andreas Voskrebenzev, Filip Klimeš, Julian Glandorf, Lea Behrendt, Marcel Gutberlet, Christopher Korz, Milan Speth, Tobias Welte and 2 more

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Article in Radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Article
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  11. Post-lung transplant surveillance in 2026: current practice, variability, and the need for standardization.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Review
  12. Article
  13. Review
  14. Article
  15. Functional Pulmonary Imaging.Journal of magnetic resonance imaging : JMRI · 2025
    Review
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Jens Vogel-Claussen *From the Department of Diagnostic and Interventional Radiology (J.V.C., T.F.K., A.V., F.K., J. Glandorf, L.B., M.G., C.K., M.S., F.W.) and Department of Respiratory Medicine (T.W., J. Gottlieb), Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany; and Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hannover, Germany (J.V.C., T.F.K., A.V., F.K., J. Glandorf, L.B., M.G., C.K., M.S., T.W., F.W., J. Gottlieb).ORCID 0000-0001-5595-6948
Till F Kaireit *From the Department of Diagnostic and Interventional Radiology (J.V.C., T.F.K., A.V., F.K., J. Glandorf, L.B., M.G., C.K., M.S., F.W.) and Department of Respiratory Medicine (T.W., J. Gottlieb), Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany; and Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hannover, Germany (J.V.C., T.F.K., A.V., F.K., J. Glandorf, L.B., M.G., C.K., M.S., T.W., F.W., J. Gottlieb).ORCID 0000-0003-4007-4904
Andreas VoskrebenzevFrom the Department of Diagnostic and Interventional Radiology (J.V.C., T.F.K., A.V., F.K., J. Glandorf, L.B., M.G., C.K., M.S., F.W.) and Department of Respiratory Medicine (T.W., J. Gottlieb), Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany; and Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hannover, Germany (J.V.C., T.F.K., A.V., F.K., J. Glandorf, L.B., M.G., C.K., M.S., T.W., F.W., J. Gottlieb).ORCID 0000-0001-5699-1841
Filip KlimešFrom the Department of Diagnostic and Interventional Radiology (J.V.C., T.F.K., A.V., F.K., J. Glandorf, L.B., M.G., C.K., M.S., F.W.) and Department of Respiratory Medicine (T.W., J. Gottlieb), Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany; and Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hannover, Germany (J.V.C., T.F.K., A.V., F.K., J. Glandorf, L.B., M.G., C.K., M.S., T.W., F.W., J. Gottlieb).ORCID 0000-0003-2715-0757
Julian GlandorfFrom the Department of Diagnostic and Interventional Radiology (J.V.C., T.F.K., A.V., F.K., J. Glandorf, L.B., M.G., C.K., M.S., F.W.) and Department of Respiratory Medicine (T.W., J. Gottlieb), Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany; and Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hannover, Germany (J.V.C., T.F.K., A.V., F.K., J. Glandorf, L.B., M.G., C.K., M.S., T.W., F.W., J. Gottlieb).ORCID 0000-0003-1927-9876
Lea BehrendtFrom the Department of Diagnostic and Interventional Radiology (J.V.C., T.F.K., A.V., F.K., J. Glandorf, L.B., M.G., C.K., M.S., F.W.) and Department of Respiratory Medicine (T.W., J. Gottlieb), Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany; and Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hannover, Germany (J.V.C., T.F.K., A.V., F.K., J. Glandorf, L.B., M.G., C.K., M.S., T.W., F.W., J. Gottlieb).ORCID 0000-0001-8851-1849
Marcel GutberletFrom the Department of Diagnostic and Interventional Radiology (J.V.C., T.F.K., A.V., F.K., J. Glandorf, L.B., M.G., C.K., M.S., F.W.) and Department of Respiratory Medicine (T.W., J. Gottlieb), Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany; and Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hannover, Germany (J.V.C., T.F.K., A.V., F.K., J. Glandorf, L.B., M.G., C.K., M.S., T.W., F.W., J. Gottlieb).
Christopher KorzFrom the Department of Diagnostic and Interventional Radiology (J.V.C., T.F.K., A.V., F.K., J. Glandorf, L.B., M.G., C.K., M.S., F.W.) and Department of Respiratory Medicine (T.W., J. Gottlieb), Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany; and Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hannover, Germany (J.V.C., T.F.K., A.V., F.K., J. Glandorf, L.B., M.G., C.K., M.S., T.W., F.W., J. Gottlieb).ORCID 0000-0002-2023-7721
Milan SpethFrom the Department of Diagnostic and Interventional Radiology (J.V.C., T.F.K., A.V., F.K., J. Glandorf, L.B., M.G., C.K., M.S., F.W.) and Department of Respiratory Medicine (T.W., J. Gottlieb), Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany; and Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hannover, Germany (J.V.C., T.F.K., A.V., F.K., J. Glandorf, L.B., M.G., C.K., M.S., T.W., F.W., J. Gottlieb).ORCID 0000-0002-7561-2939
Tobias WelteFrom the Department of Diagnostic and Interventional Radiology (J.V.C., T.F.K., A.V., F.K., J. Glandorf, L.B., M.G., C.K., M.S., F.W.) and Department of Respiratory Medicine (T.W., J. Gottlieb), Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany; and Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hannover, Germany (J.V.C., T.F.K., A.V., F.K., J. Glandorf, L.B., M.G., C.K., M.S., T.W., F.W., J. Gottlieb).ORCID 0000-0002-9947-7356
Frank WackerFrom the Department of Diagnostic and Interventional Radiology (J.V.C., T.F.K., A.V., F.K., J. Glandorf, L.B., M.G., C.K., M.S., F.W.) and Department of Respiratory Medicine (T.W., J. Gottlieb), Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany; and Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hannover, Germany (J.V.C., T.F.K., A.V., F.K., J. Glandorf, L.B., M.G., C.K., M.S., T.W., F.W., J. Gottlieb).ORCID 0000-0002-6285-8403
Jens GottliebFrom the Department of Diagnostic and Interventional Radiology (J.V.C., T.F.K., A.V., F.K., J. Glandorf, L.B., M.G., C.K., M.S., F.W.) and Department of Respiratory Medicine (T.W., J. Gottlieb), Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany; and Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hannover, Germany (J.V.C., T.F.K., A.V., F.K., J. Glandorf, L.B., M.G., C.K., M.S., T.W., F.W., J. Gottlieb).ORCID 0000-0002-9540-9022
Medizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Chronic lung allograft dysfunction (CLAD), the physiologic correlate of chronic rejection, remains a major barrier to long-term survival following lung transplant. Biomarkers for early prediction of future transplant loss or death due to CLAD might open a window of opportunity for early diagnosis and treatment of CLAD. Purpose To evaluate the prognostic use of phase-resolved functional lung (PREFUL) MRI in predicting CLAD-related transplant loss or death. Materials and Methods In this prospective, longitudinal, single-center study, PREFUL MRI-derived ventilation and parenchymal lung perfusion parameters of bilateral lung transplant recipients without clinically suspected CLAD were assessed 6-12 months (baseline) and 2.5 years (follow-up) after transplant. MRI scans were acquired between August 2013 and December 2018. Regional flow volume loop (RFVL)-based ventilated volume (VV) and perfused volume were calculated using thresholds and spatially combined as ventilation-perfusion (V/Q) matching. Spirometry data were obtained on the same day. Exploratory models were calculated using receiver operating characteristic analysis, and subsequent survival analyses (Kaplan-Meier, hazard ratios [HRs]) of CLAD-related graft loss were performed to compare clinical and MRI parameters as clinical end points. Results At baseline MRI examination, 132 clinically stable patients of 141 patients (median age, 53 years [IQR, 43-59 years]; 78 men) were included (nine were excluded for deaths not associated with CLAD), 24 of which had CLAD-related graft loss (death or retransplant) within the observational period of 5.6 years. PREFUL MRI-derived RFVL VV was a predictor of poorer survival (cutoff, 92.3%; log-rank

Indexed as

LungLung TransplantationAllograftsChronic DiseaseHumansMagnetic Resonance ImagingMaleMiddle AgedPerfusionProspective StudiesRetrospective Studies

Identifiers

PMID37070996
OpenAlexW4366240162

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.