Evidence map›Paper›PMID 37070753›Full record

ArticleDevelopment (Cambridge, England)2023

Direct force measurement and loading on developing tissues in intact avian embryos.

Chon U Chan, Fengzhu Xiong, Arthur Michaut, Joana M N Vidigueira, Olivier Pourquié, L Mahadevan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Mechanics of compression-driven morphogenesis.Development (Cambridge, England) · 2026
    Review
  2. Article
  3. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Chon U ChanJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0002-9047-057X
Fengzhu XiongJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0002-6153-0254
Arthur MichautDepartment of Pathology, Brigham Women's Hospital and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-1226-0021
Joana M N VidigueiraWellcome Trust/CRUK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK.ORCID 0000-0002-3756-2854
Olivier PourquiéDepartment of Pathology, Brigham Women's Hospital and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-5189-1227
L MahadevanJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0002-5114-0519
Brigham and Women's Hospital · USAgency for Science, Technology and Research · SGHarvard University · USUniversity of Cambridge · GB

Funding

Mechanics of Vertebrate Embryo ElongationR01HD097068 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI POURQUIE, OLIVIER · 2018 to 2022
$2.7M
Cellular and Physical Mechanisms of Developmental SymmetryK99HD092582 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI XIONG, FENGZHU · 2018 to 2019
$219k
NICHD NIH HHS K99 HD092582NICHD NIH HHS R01 HD097068Wellcome TrustWellcome Trust 215439/Z/19/Z
6 · The paper itself

Abstract

Developmental morphogenesis is driven by tissue stresses acting on tissue rheology. Direct measurements of forces in small tissues (100 µm-1 mm) in situ, such as in early embryos, require high spatial precision and minimal invasiveness. Here, we introduce a control-based approach, tissue force microscopy (TiFM), that integrates a mechanical cantilever probe and live imaging with closed-loop feedback control of mechanical loading in early chicken embryos. By testing previously qualitatively characterized force-producing tissues in the elongating body axis, we show that TiFM quantitatively captures stress dynamics with high sensitivity. TiFM also provides the means to apply stable, minimally invasive and physiologically relevant loads to drive tissue deformation and to follow the resulting morphogenetic progression associated with large-scale cell movements. Together, TiFM allows us to control tissue force measurement and manipulation in small developing embryos, and promises to contribute to the quantitative understanding of complex multi-tissue mechanics during development.

Indexed as

ChickensMechanical PhenomenaAnimalsChick EmbryoMorphogenesisAvian embryoBody axisFeedback-controlLoadingTissue forces

Identifiers

PMID37070753
PMCPMC10259510
OpenAlexW4366240872

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.