ArticleBMC biology2023
Haplotype-resolved genomes of two buckwheat crops provide insights into their contrasted rutin concentrations and reproductive systems.
Article in BMC biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 22 citations in OpenAlex.
- CRISPR/Cas9-mediatedFrontiers in plant science · 2026Article
- A Near Telomere-To-Telomere Genome Assembly and Graph-Based Pangenome of Tartary Buckwheat (Fagopyrum tataricum).Plant biotechnology journal · 2025Article
- Seed shattering in common buckwheat (Fagopyrum esculentum): insights from RNA-seq and morphological analysis.BMC plant biology · 2025Article
- Phylogenomics provides comprehensive insights into the evolutionary relationships among cultivated buckwheat species.Genome biology · 2025Article
- Article
- Genome-Wide Association Studies Reveal the Genetic Architecture of Ionomic Variation in Grains of Tartary Buckwheat.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Exploring intra- and intergenomic variation in haplotype-resolved pangenomes.Plant biotechnology journal · 2025Article
- Chromosome-level genome assembly of the tetraploid medicinal and natural dye plant Persicaria tinctoria.Scientific data · 2024Article
- Evolution and Domestication of a Novel Biosynthetic Gene Cluster Contributing to the Flavonoid Metabolism and High-Altitude Adaptability of Plants in the Fagopyrum Genus.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Multi-omics identification of a key glycosyl hydrolase gene FtGH1 involved in rutin hydrolysis in Tartary buckwheat (Fagopyrum tataricum).Plant biotechnology journal · 2024Article
- A chromosome-level genome reveals genome evolution and molecular basis of anthraquinone biosynthesis in Rheum palmatum.BMC plant biology · 2024Article
- Haplotype-resolved genome ofHorticulture research · 2024Article
- Functional characterization ofFrontiers in plant science · 2024Article
- Haplotype-resolved genomes of two buckwheat crops provide insights into their contrasted rutin concentrations and reproductive systems.BMC biology · 2023Article
- Efficient Agrobacterium-mediated transformation and genome editing ofFrontiers in plant science · 2023Article
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9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTwo widely cultivated annual buckwheat crops, Fagopyrum esculentum and F. tataricum, differ from each other in both rutin concentration and reproductive system. However, the underlying genetic mechanisms remain poorly elucidated.
resultsHere, we report the first haplotype-resolved chromosome-level genome assemblies of the two species. Two haplotype genomes of F. esculentum were assembled as 1.23 and 1.19 Gb with N50 = 9.8 and 12.4 Mb, respectively; the two haplotype genomes of F. tataricum were 453.7 and 446.2 Mb with N50 = 50 and 30 Mb, respectively. We further annotated protein-coding genes of each haplotype genome based on available gene sets and 48 newly sequenced transcriptomes. We found that more repetitive sequences, especially expansion of long terminal repeat retrotransposons (LTR-RTs), contributed to the large genome size of F. esculentum. Based on the well-annotated sequences, gene expressions, and luciferase experiments, we identified the sequence mutations of the promoter regions of two key genes that are likely to have greatly contributed to the high rutin concentration and selfing reproduction in F. tartaricum.
conclusionsOur results highlight the importance of high-quality genomes to identify genetic mutations underlying phenotypic differences between closely related species. F. tataricum may have been experienced stronger selection than F. esculentum through choosing these two non-coding alleles for the desired cultivation traits. These findings further suggest that genetic manipulation of the non-coding promoter regions could be widely employed for breeding buckwheat and other crops.
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