SynthesisInternational journal of colorectal disease2023
The role of viruses in human acute appendicitis: a systematic literature review.
Synthesis in International journal of colorectal disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Gene expression patterns associated with influenza A and type I hypersensitivity in childhood appendicitis.World journal of pediatrics : WJP · 2026Article
- Expanded Dengue and the Digestive System: A Systematic Review and Meta-Analysis.Tropical medicine and infectious disease · 2026Review
- The occurrence of appendicitis varies according to latitudes and seasons: A French national retrospective study.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Association of ambient temperature and influenza-like illness with acute appendicitis: an ecological study using 22-year data.BMC public health · 2025Article
- Acute Appendicitis Occurring in Dengue Fever: A Case Report and Review of the Literature.Case reports in infectious diseases · 2025Article
- Parasitic appendicitis, what do we know?-a literature review.Translational gastroenterology and hepatology · 2025Review
- NETworking for Health and in Disease: Neutrophil Extracellular Traps in Pediatric Surgical Care.Children (Basel, Switzerland) · 2024Review
- Can Salmonella typhi Cause Acute Appendicitis?Cureus · 2024Article
- Addressing the Knowledge Deficit in Hospital Bed Planning and Defining an Optimum Region for the Number of Different Types of Hospital Beds in an Effective Health Care System.International journal of environmental research and public health · 2023Review
- Trends in Simple and Complex Appendicitis in Children and the Potential Correlation to Common Viral Pathogens-A Retrospective Cohort Study between 2010 and 2019 in The Netherlands.Children (Basel, Switzerland) · 2023Article
- Flow cytometric characterization of cecal appendix lymphocyte subpopulations in children: a pilot study.Pediatric surgery international · 2023Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere have been debates about the human appendix function, and while previous research suggested it might be a vestigial organ with no functional significance, recent studies have pointed out that it might have an important role in the immune system. Acute appendicitis (AA) is a common cause of emergency abdominal surgery in the world. Some epidemiologic investigations have found an association between appendicitis and viral infections. In this study, we have reviewed systematically articles to discover viral infections that cause appendicitis and find any possible correlations between the two.
methodsThis systematic review was performed by searching among electronic databases including Web of Science, PubMed, Scopus, and EMBASE on viruses and appendicitis topics.
resultsConducted search leads to 983 results in all databases after the duplicate removal and screening by title, abstract, and full-text based on inclusion criteria lead to 19 studies. There were several assays to detect the viruses, which are thought to be AA causative agents. RT-PCR and immunoassays were the mainstay methods to detect the probable cause.
conclusionInvestigations suggested that some viruses including measles virus (MV), influenza virus, dengue fever virus (DFV), human immunodeficiency virus (HIV), human herpesviruses, rotavirus, and adenovirus are associated with acute appendicitis. Despite the available reports, the specific mechanisms behind the relationship between acute appendicitis and viral infections are yet to be understood. Therefore, further investigations are necessary to find out the pathogenesis and pathophysiology of viral complications in appendicitis.
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