Evidence map›Paper›PMID 37069381›Full record

ReviewArchives of gynecology and obstetrics2024

Molecular insights into placental iron transfer mechanisms and maternofetal regulation.

Sreenithi Santhakumar, Eunice S Edison

Abstract readReview
PubMed Publisher
In one paragraph

Review in Archives of gynecology and obstetrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sreenithi SanthakumarDepartment of Haematology, Christian Medical College, Vellore, Tamil Nadu, 632 004, India.
Eunice S EdisonDepartment of Haematology, Christian Medical College, Vellore, Tamil Nadu, 632 004, India. eunice@cmcvellore.ac.in.ORCID 0000-0002-9726-1324
Christian Medical College, Vellore · IN

Funding

DEPARTMENT OF SCIENCE AND TECHNOLOGY[IN] DST/INT/POL/P-7/2014
6 · The paper itself

Abstract

purposeAdequate iron transportation from the mother across the placenta is crucial for fetal growth and establishing sufficient iron stores in neonates at birth. The past decade has marked significant discoveries in iron metabolism with the identification of new players and mechanisms. Immunohistochemical studies rendered valuable data on the localization of substantial iron transporters on placental syncytiotrophoblasts. However, the function and regulation of maternal-placentofetal iron transporters and iron handling is still elusive and requires more attention.

methodsA thorough literature review was conducted to gather information about placental iron transfer, the role of regulators and maintenance of iron homeostasis.

resultsThe role of classical and new players in maternal-fetal iron transport and the regulation in the placenta has been addressed in this review. Animal and human studies have been discussed. The role of placental iron regulation in thalassemia and hemochromatosis pregnancies has been reviewed.

conclusionsThe current advances that highlight the mechanisms of placental iron regulation and transport in response to maternal and fetal signals have been presented.

Indexed as

IronPlacentaAnimalsFemaleFetusHumansInfant, NewbornMaternal-Fetal ExchangeMembrane Transport ProteinsPregnancyTrophoblastsIronMembrane Transport ProteinsIron transportPlacentaPregnancy

Identifiers

PMID37069381
OpenAlexW4366239720

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.