Evidence map›Paper›PMID 37069353›Full record

ArticleCancer immunology, immunotherapy : CII2023

The pathogenetic significance of exhausted T cells in a mouse model of mature B cell neoplasms.

Asuka Shibamiya, Yurie Miyamoto-Nagai, Shuhei Koide, Motohiko Oshima, Ola Rizq, Kazumasa Aoyama, Yaeko Nakajima-Takagi, Rei Kato, Kensuke Kayamori, Yusuke Isshiki and 11 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 67% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 1 country.

Asuka ShibamiyaDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Yurie Miyamoto-NagaiDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Shuhei KoideDivision of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Motohiko OshimaDivision of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Ola RizqDivision of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Kazumasa AoyamaDivision of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Yaeko Nakajima-TakagiDivision of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Rei KatoDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Kensuke KayamoriDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Yusuke IsshikiDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Nagisa Oshima-HasegawaDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Tomoya MutoDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Shokichi TsukamotoDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Yusuke TakedaDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Ryo Koyama-NasuDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Tetsuhiro ChibaDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Hiroaki HondaField of Human Disease Models, Major in Advanced Life Sciences and Medicine, Tokyo Women's Medical University, Tokyo, Japan.
Koutaro YokoteDepartment of Endocrinology, Hematology, and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
Atsushi IwamaDivision of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Emiko Sakaida *Department of Hematology, Chiba University Hospital, Chiba, Japan.
Naoya Mimura *Department of Hematology, Chiba University Hospital, Chiba, Japan. naoyamimura@chiba-u.jp.ORCID http://orcid.org/0000-0002-1717-9428
Chiba University Hospital · JPThe University of Tokyo · JPChiba University · JPTokyo Women's Medical University · JP

Funding

JSPS KAKENHI 19K08807
6 · The paper itself

Abstract

Dysfunctional anti-tumor immunity has been implicated in the pathogenesis of mature B cell neoplasms, such as multiple myeloma and B cell lymphoma; however, the impact of exhausted T cells on disease development remains unclear. Therefore, the present study investigated the features and pathogenetic significance of exhausted T cells using a mouse model of de novo mature B cell neoplasms, which is likely to show immune escape similar to human patients. The results revealed a significant increase in PD-1

Indexed as

Lymphoma, B-CellMultiple MyelomaAnimalsCD8-Positive T-LymphocytesDisease Models, AnimalHepatitis A Virus Cellular Receptor 2HumansProgrammed Cell Death 1 ReceptorTranscription FactorsHepatitis A Virus Cellular Receptor 2Programmed Cell Death 1 ReceptorTranscription FactorsExhausted T cellMature B cell neoplasmMouse modelMultiple myeloma. IMiDs

Identifiers

PMID37069353
PMCPMC10992361
OpenAlexW4366158616

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.