ArticleCardiovascular engineering and technology2023
An Image-Based Computational Fluid Dynamics Study of Mitral Regurgitation in Presence of Prolapse.
Article in Cardiovascular engineering and technology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 33 citations in OpenAlex.
- Mitral Valve Repair vs. Replacement: Hemodynamics in Valve Surgery.Reviews in cardiovascular medicine · 2026Review
- ValveFit: An analysis-suitable B-spline-based surface fitting framework for patient-specific modeling of tricuspid valves.Computer methods in applied mechanics and engineering · 2026Article
- Coupling Models of Resistive Valves to Muscle Mechanics in Cardiac Fluid-Structure Interaction Simulations.International journal for numerical methods in biomedical engineering · 2025Article
- Accurate Reconstruction of Right Heart Shape and Motion From Cine-MRI for Image-Driven Computational Hemodynamics.International journal for numerical methods in biomedical engineering · 2025Article
- Image-Based Computational Fluid Dynamics to Compare Two Repair Techniques for Mitral Valve Prolapse.Annals of biomedical engineering · 2024Article
- Advances in the Computational Assessment of Disturbed Coronary Flow and Wall Shear Stress: A Contemporary Review.Journal of the American Heart Association · 2024Review
- The role of computational methods in cardiovascular medicine: a narrative review.Translational pediatrics · 2024Review
- Turbulent blood dynamics in the left heart in the presence of mitral regurgitation: a computational study based on multi-series cine-MRI.Biomechanics and modeling in mechanobiology · 2023Article
- lifex-ep: a robust and efficient software for cardiac electrophysiology simulations.BMC bioinformatics · 2023Article
- A comprehensive mathematical model for cardiac perfusion.Scientific reports · 2023Article
- Image-driven, patient-specific simulations in the right heart: Extracting valve geometry and kinematics from blood flow data.JRSM cardiovascular diseaseArticle
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn this work we performed an imaged-based computational study of the systolic fluid dynamics in presence of mitral valve regurgitation (MVR). In particular, we compared healthy and different regurgitant scenarios with the aim of quantifying different hemodynamic quantities.
methodsWe performed computational fluid dynamic (CFD) simulations in the left ventricle, left atrium and aortic root, with a resistive immersed method, a turbulence model, and with imposed systolic wall motion reconstructed from Cine-MRI images, which allowed us to segment also the mitral valve. For the regurgitant scenarios we considered an increase of the heart rate and a dilation of the left ventricle.
resultsOur results highlighted that MVR gave rise to regurgitant jets through the mitral orifice impinging against the atrial walls and scratching against the mitral valve leading to high values of wall shear stresses (WSSs) with respect to the healthy case.
conclusionCFD with prescribed wall motion and immersed mitral valve revealed to be an effective tool to quantitatively describe hemodynamics in case of MVR and to compare different regurgitant scenarios. Our findings highlighted in particular the presence of transition to turbulence in the atrium and allowed us to quantify some important cardiac indices such as cardiac output and WSS.
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