ArticleNature communications2023
The melanocortin action is biased toward protection from weight loss in mice.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 34 citations in OpenAlex.
- Reduced melanocortin tone modulates feeding during pregnancy in mice.Nature communications · 2026Article
- Recent developments in GPCR signalling in appetite regulation.Bioscience reports · 2026Review
- An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feeding.Metabolism: clinical and experimental · 2026Article
- Beyond satiety: unraveling the complex roles of POMC neurons in behavior and metabolism.Reviews in endocrine & metabolic disorders · 2026Review
- Selective and differential roles of PVHNature communications · 2026Article
- Identification of a neural basis for anorexia nervosa.bioRxiv : the preprint server for biology · 2026Article
- Adipokine in Metabolic Liver Disease: Adipo-Brain-Liver Cross talk.International journal of endocrinology · 2026Review
- Comprehensive insights into emerging advances in the Neurobiology of anorexia.Journal of advanced research · 2026Review
- An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feeding.bioRxiv : the preprint server for biology · 2025Article
- Maternal monosaccharide diets modulate melanocortin-4 receptor signaling and metabolic state in rat offspring.Pharmacological reports : PR · 2025Article
- Obesity dysregulates feeding-evoked response dynamics in hypothalamic satiety neurons.Scientific reports · 2025Article
- Uncovering the role of Gpr45 in obesity regulation.Molecular metabolism · 2025Article
- An alternative neural basis underlying leptin resistance.Cell reports · 2025Article
- Novel neural pathways targeted by GLP-1R agonists and bariatric surgery.Pflugers Archiv : European journal of physiology · 2025Review
- Medical Management of Obesity: Current Trends and Future Perspectives.Methodist DeBakey cardiovascular journal · 2025Review
- Hunting for heroes: Brain neurons mediating GLP-1R agonists in obesity treatment.Obesity medicine · 2024Article
- Methodology for Studying Hypothalamic Regulation of Feeding Behaviors.Methods and protocols · 2024Review
- Hypothalamic AgRP neurons regulate the hyperphagia of lactation.Molecular metabolism · 2024Article
- Article
- AZGP1 in POMC neurons modulates energy homeostasis and metabolism through leptin-mediated STAT3 phosphorylation.Nature communications · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
The melanocortin action is well perceived for its ability to regulate body weight bidirectionally with its gain of function reducing body weight and loss of function promoting obesity. However, this notion cannot explain the difficulty in identifying effective therapeutics toward treating general obesity via activation of the melanocortin action. Here, we provide evidence that altered melanocortin action is only able to cause one-directional obesity development. We demonstrate that chronic inhibition of arcuate neurons expressing proopiomelanocortin (POMC) or paraventricular hypothalamic neurons expressing melanocortin receptor 4 (MC4R) causes massive obesity. However, chronic activation of these neuronal populations failed to reduce body weight. Furthermore, gain of function of the melanocortin action through overexpression of MC4R, POMC or its derived peptides had little effect on obesity prevention or reversal. These results reveal a bias of the melanocortin action towards protection of weight loss and provide a neural basis behind the well-known, but mechanistically ill-defined, predisposition to obesity development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.